小半夏加茯苓胶囊对顺铂诱发犬和家鸽呕吐的影响  

Effect of antiemetic of Banxia Fuling Capsule on emesis induced by cisplatin

作　　者：陈晓燕[1] 王家辉[2] 柏玉举[2] 龚其海[1] 吴芹[1] 孙安盛[1] 

机构地区：[1]遵义医学院,贵州遵义563003 [2]遵义医学院附属肿瘤医院,贵州遵义563003

出　　处：《中成药》2007年第12期1749-1751,共3页Chinese Traditional Patent Medicine

基　　金：贵州省中医药管理局(NO.D288)

摘　　要：目的:观察小半夏加茯苓胶囊(生姜、半夏、茯苓等)(BFC)对顺铂诱发家鸽呕吐的防治作用;探讨BFC的止吐作用与5-羟色胺之间的关系。方法:犬、家鸽静脉注射顺铂模拟化疗呕吐模型,分别食饵、灌胃预防给药,观察BFC对犬、家鸽呕吐的影响;同时采用荧光分光光度法检测家犬血清、家鸽脑干和小肠组织中5-HT的含量。结果:BFC预防给药可降低犬及家鸽呕吐发生率,减少呕吐发作次数;同时降低犬血清及家鸽脑干和小肠组织中5-HT含量。结论:BFC可防治顺铂引起的家鸽呕吐;此作用可能与抑制小肠和脑干5-HT的生成与释放有关。AIM： To investigate the antiemetic effect of preadministration of Banxia Fuling Capsule （Rhizoma Zingiberis recens, Rhizoma Pinelliae, Poria, etc） （BFC） in pigeons and dogs, and to explore the relationship between antiemetic effect of BFC and 5-hydroxytryptamine （5-HT）. METHODS： The pigeons and dogs were pretreated with BFC for 3 days. Acute emesis of pigeons and dogs induced by intravenously injecting cisplatin were observed. The concentraction of 5-HT in the serum, small intestine and brainstem of the animals were determined by spectrofluorimetry. RESULTS： The number and incidence of the emesis decreased in the treatment of BFC in dogs and pigeons ; The levels of 5-HT in brainstem and small intestine decreased in pigeons, and so was it in the serum of dogs. CONCLUSION： BFC may inhibit emesis induced by cisplatin in dogs and pigeons, the antiemetic effect of BFC may decrease the synthesis and release of 5-HT in brainstem and small intestine.

关 键 词：小半夏加茯苓胶囊 止吐作用:5-HT 犬 家鸽 

分 类 号：R285.6[医药卫生—中药学]