PGC-1基因Thr394Thr多态性与Ⅱ型糖尿病关系的研究  

Study on relationship of PGC-1 gene Thr 394 Thr polymorphism and type 2 diabetes mellitus

作　　者：张子波[1] 吕福庆[2] 王伟杰[3] 李博[1] 杨康鹃[1] 金元哲[4] 

机构地区：[1]延边大学基础医学院细胞生物学与医学遗传学教研室,吉林延吉133000 [2]敦化市医院内科,吉林敦化133700 [3]珲春市医院内分泌科,吉林珲春133300 [4]延边大学基础医学院生理学与病理生理学教研部,吉林延吉133000

出　　处：《延边大学医学学报》2007年第4期235-238,共4页Journal of Medical Science Yanbian University

摘　　要：[目的]探讨延边地区朝鲜族及汉族人群PGC-1基因Thr 394 Thr多态性与Ⅱ型糖尿病的相关性.[方法]采用聚合酶链反应-单链构象多态性(PCR-SSCP)方法对104例糖耐量正常者和113例Ⅱ型糖尿病患者的PGC-1基因Thr 394 Thr多态性基因型进行对照研究.[结果]朝鲜族和汉族正常人PGC-1基因Thr 394 Thr多态性的A等位基因频率分别为23.3%,20.7%;糖耐量正常组及Ⅱ型糖尿病组人群的PGC-1基因Thr 394 Thr多态性的A等位基因频率均为22.1%.[结论]延边地区朝鲜族和汉族人群PGC-1基因Thr 394 Thr多态性间无显著性差异;PGC-1基因Thr 394 Thr多态性与Ⅱ型糖尿病发病无相关性.OBJECTIVE To determine the correlation of peroxisome proliferators activated receptor-7 coactivator 1 （PGC-1） gene Thr 394 Thr polymorphism and type 2 diabetes mellitus （T 2 DM） for Korean- Chinese and Han nationality in Yanbian area. METHODS PGC-1 gene Thr 394 Thr polymorphism in 104 cases of normal glucose tolerant （NGT） and 113 cases of T 2 DM was detected by PCR-SSCP. RESULTS The A allele frequencies of NGT in Korean-Chinese and Han nationality were 23.3% and 20.7%, respectively, and there was no significant difference between two groups. The A allele frequencies of NGT and T 2 DM subjects were all of 22.1% . CONCLUSION There was no difference in frequency distribution of PGC-1 gene Thr 394 Thr polymorphism between Korean-Chinese and Han nationality in Yanbian area, and the PGC-1 gene Thr 394 Thr polymorphism was not associated with T 2 DM.

关 键 词：多态性 单核苷酸 糖尿病 Ⅱ型 人种群 

分 类 号：R446.5[医药卫生—诊断学]