N型钙通道阻断剂SNX-111对福尔马林诱导的大鼠内脏痛的镇痛作用  

Analgesic research of N-type calcium channel blocker SNX-111 in visceral pain of rat induced by formalin

作　　者：张颜波[1] 吕国蔚[2] 牛敬忠[1] 

机构地区：[1]泰山医学院附属医院神经内科,山东泰安271000 [2]首都医科大学低氧医学研究所

出　　处：《中国行为医学科学》2007年第12期1064-1066,共3页Chinese Journal of Behavioral Medical Science

基　　金：基金项目：国家自然基金资助项目（30070949）;北京市自然基金资助项目（7962009）

摘　　要：目的进行福尔马林诱导的大鼠内脏痛行为及N型钙通道阻断剂SNX-111镇痛效果观察和评价。方法采用福尔马林直肠黏膜下注射复制的内脏痛模型，鞘内注射SNX-111（0．1μg／kg；0．5μg／kg；1μg／kg）观察镇痛效果。致痛后以15min为一个时间段，共记录2h，分别计算疼痛分数。结果各组大鼠在注射福尔马林后30min均达到疼痛评分的最大值[（39．88±5．32）分-（89．84±8．61）分]，从注射福尔马林后45-120min内，疼痛评分逐渐降低[（2．96±0．91）分-（38．50±5．16）分]。前60min内行为表现主要以伸展身体、腹部收缩、全身收缩反应为主；而在后60min内主要以腹部舔食和轻咬反应为主。SNX-111能明显减少疼痛评分[（4．48±0．45）分-（46．83±5．28）分]，抑制内脏疼痛反应，SNX-111剂量越大，镇痛效果越显著（P〈0．01或P〈0．05）。结论福尔马林具有较强的内脏致痛效应，疼痛分数能反映内脏疼痛程度，可作为量化指标；SNX-111对内脏痛具有明显的、剂量依赖性的镇痛效果。Objective To observe and assess visceralgia behavior of the rat induced by formalin and anal-gesic effect of N-type calcium channel blocker SNX-111. Methods A model of visceralgia induced by formalin injection in the submucosa of rectum was used, SNX-111 （0. 1μg/kg;0.5μg/kg; 1μg/kg） was injected intrathe-cally to observe analgesic effect of it, A numerical score for pain behaviors was recorded every 15 minutes for 2 hours, Results The scores were at the highest level in 30-min period （39.88±5.32 - 89.84±8.61 ） and re- duced in late phases（2.96±0.91-38.50±5.16）. Body stretching, contraction of the flanks and whole body contraction were predominant in the former 60 minutes, while abdominal licking and nibbling were predominant in the late 60 minutes. SNX-111 could significantly reduce pain scores （4.48±0.45 - 46.83±5.28 ） and alleviate pain reaction. The larger dose of SNX-111 used, the better analgesic effect had（ P 〈 0.01, P 〈0.05 ）, Conclusion Formalin has a significant algesie effect, and pain scores can reflect the degree of visceralgia and be a quan-tifiable index, SNX-111 has a significant and dose-dependant analgesic effect on visceralgia.

关 键 词：内脏痛 福尔马林 SNX-111 疼痛分数 

分 类 号：R686[医药卫生—骨科学]