卡托普利与洛伐他汀联用对阿霉素肾病大鼠血清TNF-α的影响  

Effect of Captopril and Lovastatin Combined on the Serum Level of TNF-α in Male Sprague-Dawlay Rat Models of Nephropathy Induced by Adriamycin

作　　者：张道友[1] 吴仁胜[1] 陈忠辉[1] 杨沿浪[1] 苏惠[1] 高潮清[1] 杨利才[1] 徐海红[1] 

机构地区：[1]皖南医学院附属弋矶山医院肾内科,241001

出　　处：《放射免疫学杂志》2007年第6期488-490,共3页Journal of Radioimmanology

摘　　要：目的:探讨卡托普利与洛伐他汀联用对阿霉素肾病大鼠血清肿瘤坏死因子-α(TNF-α)的影响及保护肾脏作用的可能机理。方法:雄性SD大鼠150只,适应性喂养2周后,随机抽取18只为对照组(A组);另外132只制作阿霉素肾病模型,造模2周末,4只造模失败,8只死亡,120只造模成功的大鼠随机分为4组:B组为模型对照组(n=30),C为卡托普利治疗组(n=30),D组为洛伐他汀治疗组(n=30),E组为卡托普利和洛伐他汀联合治疗组(n=30)。分别于2、4、6周末,遵循随机化原则,按n=6,分层抽取各组样本,收集24h尿液及血液标本待测。结果:和模型组比较,卡托普利组、洛伐他汀组及联合治疗组血清TNF-α及胆固醇、三酰甘油浓度均降低,蛋白尿减少,血清白蛋白浓度升高;两药联用疗效更为明显。结论:卡托普利与洛伐他汀联用可进一步降低血清TNF-α浓度,对阿霉素肾病大鼠具有添加的肾脏保护作用。Objective To study the possible protective effect of combined captopril and lovastatin treatment on kidney function through lowering of serum TNF - α levels in rat models of adriarnycin nephropathy. Methods Male rat models of nephropathy （24h urinary protein 〉 100mg, n = 120） were successfully prepared with intravenous injection of adriamycin （5.5mg/kg）. The models were divided into 4 equal numbered groups （n =30） （1） not specifically treated （2） treated with captopril （30mg/kg/d） garage （3） treated with lovastatin （15mg/kg/d） gavage （4） treated with captopril and lovastatin combined at the above dosage. Serum TNF - α, albumin, cholesterol and triglyeeride levels and 24h urine protein contents were determined in 6 models from each group at 2,4 and 6 weeks. Results The serum TNF - α, cholesterol and triglyceride levels were significantly lower in the models of 3 treated groups than those in untreated models, especially with the combined treated ones. The 24h urinary protein excretion was reduced with elevated serum albumin levels. Conclusion Combined administration of captopril and lovastatin resulted in the lowest serum TNF - α levels with most favorable protection of renal fimction in rat models of nephropathy induced by adriamycin.

关 键 词：阿霉素肾病 卡托普利 洛伐他汀 肿瘤坏死因子-α 蛋白尿 

分 类 号：R285.5[医药卫生—中药学]