联检CA15-3、CEA、TSGF及放射性核素骨显像对乳腺癌骨转移诊断的临床意义  

Clinical Value of Combined Detection of Serum Tumor Markers and Whole Body Bone Scan for Diagnosis of Bone Metastases from Breast Cancer

作　　者：高超[1] 赵晶[1] 刘德生[1] 张敬川[1] 季雪静[1] 候先存[1] 

机构地区：[1]徐州医学院附属医院肿瘤科,221002

出　　处：《放射免疫学杂志》2007年第6期579-580,共2页Journal of Radioimmanology

摘　　要：目的:探讨联检血清肿瘤标志物和放射性核素骨显像对诊断乳腺癌骨转移的临床价值。方法:应用化学发光免疫检测技术检测了124例乳腺癌患者血清CA15-3、CEA、TSGF三种肿瘤标志物,应用SPECT对所有患者全身进行骨扫描检查,以明确有无转移。结果:124例患者中38例临床诊断为乳腺癌骨转移,乳腺癌骨转移组患者血清CA15-3、CEA、TSGF显著高于未转移组和正常对照组(P<0.01),其阳性预测值分别为76.78%、80%和82.14%,阴性预测值分别为82.41%、86.74%和84.29%。结论:CA15-3、CEA、TSGF具有诊断乳腺癌骨转移的临床价值,而联检肿瘤标志物结合全身骨扫描可以提高乳腺癌骨转移诊断的准确性。Objective To study the clinical value of serum tumor marker determination and whole body bone scan for diagnosis of bone metastases from breast cancer. Mothods Serum tumor markers （CA15 -3, CEA, TSGF）were detected with CLIA and whole body bone scan were investigated by SPECT in 124 breast cancer patients. Rosults In 124 patients, 38 patients were diagnosed as positive for bone metastases with whole body bone scan. The positive predicting values of CA15 -3, CEA, TSGF were 76.78%, 80% and 82. 14%, and the negative predicting values of CA15 -3, CEA, TSGF were 82.41%, 86.74% and 84.29% respectively. The levels of CA15 -3, CEA, TSGF in patients with bone metastases were significantly higher than those in patients without metastasis and the controls （P〈0.01）. Conclusion Determination of levels of serum tumor markers CA15-3, CEA, TSGF is helpful for diagnosis of bone metastases from breast cancer. Combined detection of CA15 - 3, CEA, TSGF could increase the sensitivty and accuracy of diagnosing bone metastases.

关 键 词：血清肿瘤标志物 全身骨扫描 乳腺癌 骨转移 

分 类 号：R737.9[医药卫生—肿瘤]