2型糖尿病视网膜病变与β_3-肾上腺素能受体基因多态性关系的初步研究  

Initial Research of Relationship between Type ⅡDiabetic Retinopathy and Gene Polymorphism

作　　者：刘昊凌[1] 徐莹[1] 阴慧清[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院内分泌科,黑龙江哈尔滨150001

出　　处：《黑龙江医学》2007年第12期897-899,共3页Heilongjiang Medical Journal

摘　　要：目的研究β3-肾上腺素能受体(β3-AR)基因Trp64Arg突变在2型糖尿病视网膜病变(DR)中作用。方法42例2型糖尿病患者,无视网膜病变组14例、背景性视网膜病变组14例、增值性视网膜病变组14例。采用PCR-PELF法检测β3-AR基因Trp64 Arg错义突变;同时检测体重指数(BMI)、血压、空腹血糖、血脂、糖化血红蛋白A1c(HBA1c)等指标。结果42例中国北方地区2型糖尿病患者Arg64等位基因频率为0.12。突变频率在视网膜病变组与非视网膜病变组;背景性视网膜病变组与增殖性视网膜病变组间的差异无显著性(P>0.05);2型糖尿病患者Arg携带组BMI、血甘油三酯水平高于非携带组(P<0.05)。结论β3-AR基因Trp 64Arg突变与2型糖尿病病人血脂异常分布及脂代谢紊乱有关,但与DR及其严重程度无关联,β3-AR基因可能不是2型糖尿病视网膜病变的风险基因。Objective To research the role of the mutation in gene Trp64Arg located in β3 - AR in type 2 diabetic retinopathy. Methods The 42 patients with tppe 2 diabetes were divides into three groups, the group of non - retinopathy, background retinopathy and increased retinopathy , each one contained 14 patients. The missense mutation of gene Trp64Arg located in β3 - AR had been detected using PCR - PELF. The BMI,BP, BFS,blood - fat and HBAlc had been detected at the same time. Results The Arg64 allele frequency of the 42 patients who had type 2 diabetes and lived in the north of China was 0.12. The mutation frequency had not significance difference between the retinopathy group and non- retinopathy group. It also had not significance difference between the background retinopathy group and proliferative retinopathy group（ P 〉 0.05） ; The BMLblood - fat level of the group of Arg carrier with tppe 2 diabetes was higher than the group of non - Arg carrier（ P 〈 0.05）. Conclusion The mutation in gene Trp64Arg located in β3 - AR was concerned with the body fat abnormality and lipid metabolism disorder of patients with tppe 2 diabetes, but was not concerned with the Severity degree. Gene β3 - AR may not be the risk gene of the type 2 diabetic retinopathy.

关 键 词：Β-肾上腺素能受体 基因多态性 2型糖尿病 糖尿病视网膜病变 

分 类 号：R587.1[医药卫生—内分泌]