动脉粥样硬化的分子核医学研究进展  

The development of molecular nuclear medicine in atherosclerosis

作　　者：黄代娟[1] 张永学[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院核医学科,湖北省分子影像学重点实验室,武汉430022

出　　处：《国际放射医学核医学杂志》2007年第5期264-266,273,共4页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：动脉粥样硬化涉及到全身多处重要的动脉，是导致成人死亡的主要原因之一。早期诊断动脉粥样硬化斑块尤其是不稳定斑块具有重要的临床意义。该疾病病理生理学的不断发展，显示出包括“金标准”X射线血管造影在内的常用显像方法的一些不足以及对更加完善的显像技术的需求。分子核医学技术利用核素标记参与动脉粥样硬化形成的中间物质或其表面的血栓进行显像，无创伤性地检测斑块的数量、进展程度、分布和组成，为早期发现动脉粥样硬化提供了可靠依据。Atherosclerosis involves many essential arteries of whole body and it is one of the main diseases that lead adults to death. So it has clinical significance to diagnose atherosclerosis in early stage and to judge its instability. Recent advances in the pathohiology of atherosclerosis have highlighted the inadequacies of the current techniques including the gold standard of X-ray angiography and the need for better imaging approaches. Molecular nuclear medicine can noninvasively detect the number, extent, distribution and component of atherosclerotic plaque, through nuclide imaging with the middle substances during the atherosclerotic process or thrombus on the surface of plaque, and thus can diagnose atherosclerosis in time.

关 键 词：动脉硬化 放射性核素显像 分子诊断技术 

分 类 号：R54[医药卫生—心血管疾病]