利用荷移反应分光光度法测定针剂中的多巴胺  

Spectrophotometric Determination of Dopamine in Injections With Charge Transfer Reaction

作　　者：龙云[1] 李东辉[1] 冯建章[2] 童沈阳[2] 

机构地区：[1]锦州医学院,锦州121001 [2]北京大学化学系,北京100871

出　　处：《分析化学》1997年第8期916-918,共3页Chinese Journal of Analytical Chemistry

摘　　要：研究了多巴胺与四氯苯醌之间的荷移反应，测得络合物组成比为１：１，摩尔吸光系数。ε＝１．６３×１０３。方法的相对标准偏差为１．２％（ｎ＝１０）。应用拟定方法测定药物制剂中多巴胺含量与药典方法一致，回收率在９４．５％～１０２％。A spectrophotometric mehtod for the determination of dopamine in injections has been developed based on a charge transfer reaction. Beer's law was obeyed in the range of 0 ～0. 064 g/L of dopamine. The molar absorptivity of complex at 480 nm was l. 63 ×l03 L. mol1. cm1 The standard deviation of the determinations was 1. 2% (n= l0). The compo- sition of the complex was found to be l: l by molar ratio and Job's mehtod. The method has been applied to the determination of dopamine in injections.

关 键 词：多巴胺 荷移反应 分光光度法 四氯苯醌 

分 类 号：R971[医药卫生—药品]