流动注射化学发光法测定异烟肼  

Determination of Isoniazide by Flow Injection Analysis / t Chemiluminescence Method

作　　者：赵芳[1] 吴远远[1] 耿征[1] 王红轩 

机构地区：[1]陕西师范大学化学系,西安710062

出　　处：《分析化学》1997年第8期927-929,共3页Chinese Journal of Analytical Chemistry

摘　　要：报道一种微量测定抗结核药物异烟肼的新方法，方法是基于异烟肼对鲁米诺－锰（Ⅱ）－高碘酸钾化学发光反应的增敏作用，建立了微量异烟肼的流动注射化学发光分析法。本法检测限（ＤＬ）是３ × １０８ｇ／ｍＬ；线性浓度范围为１．０×１０７～１．０×１０５ｇ／ｍＬ；对１．０×１０６ｇ／ｍＬ异烟肼的测定（ｎ＝６），相对标准偏差小于２％。A sensitive and selective method for determination of isoniazide has been deve1- oped. It is based on 1uminol-Mn(Ⅱ)-KlO4 chemiluminescence reaction with isoniazide as a sensitizer. The detection limit is 3 ×108g/mL. The linear range of the working curves is 1. 0 ×107～1. 0 ×105g/mL. The relative standard deviation for determination of 1. 0 ×106 g/mL isoniazide is less than 2%.

关 键 词：流动注射 化学发光 异烟肼 雷米封 

分 类 号：R978.3[医药卫生—药品]