双波长分光光度法测定复方地氯霜中氯霉素的含量  

Determination of chloramphenicol in dexamethasone and chloramphenicol compound cream by dual-wavelength spectrophotometry

作　　者：卢今[1] 柳涌[1] 

机构地区：[1]安徽省立医院药剂科,安徽合肥230001

出　　处：《安徽医药》2007年第12期1084-1085,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的建立复方地氯霜中氯霉素的含量测定方法。方法采用双波长分光光度法测定氯霉素的含量。选择测定波长为268 nm,参比波长为248 nm。结果氯霉素的平均回收率为104.3%,RSD为2.93%(n=6)。结论该方法简便、准确,适用于该制剂的质量控制。Aim To establish a method for the determination of chloramphenicol in dexamethasone and chloramphenicol compound cream. Methods A dual-wavelength spectrophotometry was used. The selected determining wavelength was 268 nm and the reference wavelength was 248 nm. Results The average recovery of chloramphenicol was 104.3 %, and RSD was 2.93% （ n = 6 ）. Conclusion This method is simple, accurate and suitable for assay of the preparation.

关 键 词：双波长分光光度法 氯霉素 复方地氯霜 含量测定 

分 类 号：R927[医药卫生—药学]