地氯雷他定含量两种测定方法的比较  

Comparison of two methods to determine desloratadine concentration

作　　者：李飞[1] 张黎娟[2] 

机构地区：[1]安徽省亳州市药品检验所 [2]安徽省亳州职业技术学院,安徽亳州236800

出　　处：《安徽医药》2007年第12期1098-1099,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的对地氯雷他定的含量测定两种方法进行比较。方法通过容量法（非水滴定法）及紫外分光光度法对地氯雷他定作含量方法比较。结果紫外分光光度法线性范围4．89～29．34mg·L^-1，r=0．99999，精密度RSD为0．73％；非水滴定法精密度RSD为0.11％。结论容量法检测地氯雷他定含量操作简单，方法快速准确。Aim To compare 2 methods of determining desloratadine concentration. Methods The content of desloratadine was determined by UV-vis and nonaqueous titration respectively. Results As for UV-vis linear range is 4.89 - 29.34 mg · L^-1, r = 0.99 999, and the precision（RSD） is 0.73%. And as for non-aqueous the precision（RSD） is 0.11%. Conclusion The method of UV-vis is very simple,quick and accurate.

关 键 词：地氯雷他定 紫外分光光度法 容量法 含量 

分 类 号：R927[医药卫生—药学]