注射用多烯紫杉醇亚微乳的制备  

Preparation of docetaxel submicron emulsion for intravenous administration

作　　者：黎玲[1] 王东凯[1] 李林穗[1] 贾军[2] 常笛[1] 艾丽 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]沈阳世恒医药科技有限公司,辽宁沈阳110179 [3]辽宁省医药工业研究院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2007年第12期736-739,共4页Journal of Shenyang Pharmaceutical University

摘　　要：目的制备静脉注射用多烯紫杉醇亚微乳;对其理化性质和溶血性进行考察。方法采用高压匀质法制备多烯紫杉醇亚微乳。在最佳处方的基础上,考察制备工艺因素对乳剂的影响。考察亚微乳的粒径和ζ-电位以及制剂的含量。采用紫外分光光度法判断其有无溶血发生。结果亚微乳粒度分布均匀,药物含量质量分数达到90%以上;试管溶血试验阴性。结论多烯紫杉醇制备成静脉注射亚微乳后可以减少不良反应,提高稳定性。Objective To prepare and characterize docetaxel submicron emulsion for intravenous administration and detect the hemolysis of the submicron emulsion. Methods The docetaxel submicron emulsion was obtained after passing the elementary emulsion through a high pressure homogenizer, and processing factors were studied based on the optimized formulation. The particle size, zeta potential and content of the docetaxel submicron emulsion were also examined. Ultraviolet spectrophotometric test were used to observe the haemolysis effects of docetaxel submicron emulsion on blood of rabbits. Results The particle sizes were welldistributed and the content of docetaxel submicron emulsion which was calculated by external standard method was more than 90 96 ; The result of tube haemolysis test of docetaxel submicron emulsion was negative. Conclusions The docetaxel submicron emulsion is stable with low toxicity.

关 键 词：亚微乳 高压匀质 溶血试验 多烯紫杉醇 

分 类 号：R94[医药卫生—药剂学]