卟啉类抗癌药物研究新进展  

Recent progress of the porphyrin-based anticancer drugs

作　　者：于克贵[1] 周成合[1] 李东红[2] 

机构地区：[1]西南大学化学化工学院,重庆400715 [2]第三军医大学野战外科研究所,重庆400042

出　　处：《化学研究与应用》2007年第12期1296-1303,共8页Chemical Research and Application

基　　金：西南大学人才引进基金(SWUB2006018)资助项目;西南大学高新技术培育基金(XSGX0602)资助项目;重庆市自然科学基金(2005BB5102)资助项目;教育部留学回国人员启动金(2004-527)资助项目

摘　　要：本文对目前以卟啉为基础的抗癌药物进行了综述,主要阐述了临床上或临床前试验中卟啉类抗癌药物新进展与构效关系。This paper reviewed the new progress in porphyrin-based anticancer drugs and their structure-activity relationship,which were mainly involved in the porphyrin-like compounds in the stages of clinical and pre-clinica1 trials. These drugs include mainly the following types： （1） Porphyrin-related structures, such as hematoporphyrin derivatives, core-raodhqed porphyrins and so on. （2） Chlorin and bacteriochlorin derivatives. （3） Phthalocyanines and related compounds. （4） Core-expanded porphyrins. （5） Clinical drugs-porphyrin conjugates. In addition,their anticancer action mechanism is also briefly introduced.

关 键 词：抗癌 卟啉 光敏剂 构效关系 

分 类 号：O623.731[理学—有机化学]