Heck反应一锅法合成3-乙氧羰基-2-甲基吲哚的研究  

Synthesis of 3-ethoxycarbonyl-2-methylindole through Heck reaction in one-pot

作　　者：张小林[1] 闫永平[1] 张环霞[2] 罗来涛[1] 

机构地区：[1]南昌大学化学系,江西南昌330047 [2]西华师范大学化学化工学院,四川南充637002

出　　处：《化学研究与应用》2007年第12期1356-1358,共3页Chemical Research and Application

摘　　要：Because of the great virtue of Heck reaction and one-pot reaction,Recently it attract many attention that how to synthesis indoles by this two methods,and has gained many progress.But It is still a problem that how to synthesis indoles through one-pot reaction with o-haloaniline and open-chain ketone.Here,for the first time,we synthesized 3-ethoxycarbonyl-2-methylindole through one-pot Heck reaction with o-bromoaniline and open-chain ketone ethyl acetoacetate.Farther work is in progress.Because of the great virtue of Heck reaction and one-pot reaction, Recently it attract many attention that how to synthesis indoles by this two methods, and has gained many progress. But It is still a problem that how to synthesis indoles through one-pot reaction with o-haloaniline and open-chain ketone. Here, for the first time, we synthesized 3-ethoxyearhonyl-2-methylindole through one- pot Heck reaction with o-hromoaniline and open-chain ketone ethyl acetoacetate. Farther work is in progress.

关 键 词：Heck反应-锅法合成3-乙氧羰基-2-甲基吲哚 

分 类 号：O626[理学—有机化学]