具有生物活性的1,4-二氢吡啶衍生物的水热法合成及结构表征  

Hydrothermal synthesis and crystal structure of 1,4-dihydropyridine derivatives

作　　者：王建平[1] 付永举[2] 王建革[1] 

机构地区：[1]洛阳师范学院化学系,河南洛阳471022 [2]河南科技大学化工与制药学院,河南洛阳471003

出　　处：《化学研究与应用》2007年第12期1379-1381,共3页Chemical Research and Application

基　　金：洛阳师范学院重点学科资助课题

摘　　要：A series of 1,4-dihydropyridine derivatives were synthesized by the reaction of aromatic aldehydes,ethyl acetoacetate and ammonium bicarbonate under hydrothermal condition.Compared to the known report,this method has the advantages of excellent yields,convenience,less pollution and friendly environment.Compound b was deterimined by X-ray single-crystal diffraction.The crystal is of monoclinic,space group C2/c with a = 19.7348(12),b=7.4285(4),c = 27.2561(16),β=106.9950(10)°,V=0.38212(4)nm3,Z=8,Dc =1.236 Mg/m3,μ=0.085 mm-1,F(000)=1520,S=1.053,R=0.0574,wR=0.1732.A series of 1,4-dihydropyridine derivatives were synthesized by the reaction of aromatic aldehydes, ethyl acetoacetate and ammonium bicarbonate under hydrothermal condition. Compared to the known report , this method has the advantages of excellent yields , convenience, less pollution and friendly environment. Compound b was detefimined by X-ray single-crystal diffraction. The crystal is of monoclinic, space group C2/c with a = 19.7348（12）A,b =7.4285（4）A,c= 27.2561（16）A,β=106.9950（10）°,V=0. 38212（4）nm^3, Z=8, De =1.236 Mg/ms, μ=0. 085 mm^-1, F（O00） =1520,S=l.053,R=0.0574,wR=0. 1732.

关 键 词：1 4-二氢吡啶衍生物 Hantzsch反应 水热合成 晶体结构 

分 类 号：O614.121[理学—无机化学]