江苏省部分地区吸毒人群HCV感染的流行病学调查  

EPIDEMIOLOGICAL SURVEY ON THE HCV INFECTION AMONG DRUG USERS IN SOME AREAS OF JIANGSU

作　　者：夏娴[1] 骆峻[1] 董静[1] 尤华[1] 钱燕华[1] 钱兴才[2] 喻荣彬[2] 

机构地区：[1]南京医科大学流行病与卫生统计学系,南京210029 [2]无锡市疾病预防控制中心

出　　处：《现代预防医学》2007年第24期4616-4618,4621,共4页Modern Preventive Medicine

基　　金：江苏省现代病原生物学重点实验室开放基金(1623);国家自然科学基金(30200232)

摘　　要：[目的]了解江苏省吸毒人群中HCV感染现状,吸毒方式、性行为特征等和HCV感染的关系,为制定干预措施提供科学依据。[方法]以南京市强制戒毒所587名戒毒人员及无锡市疾病控制中心美沙酮维持治疗(MMT)门诊收治的吸毒患者798名,共计1385例吸毒患者作为调查对象,制定统一的调查问卷进行调查,并采集静脉血检测抗-HCV抗体和肝功能等指标。[结果]1385名吸毒患者中男性占76.6%,女性占23.4%,总的抗-HCV抗体阳性率是75.5%,静脉注射吸毒者(IDUs)的阳性率为88.5%,显著高于肌肉/皮下注射(60.0%)和口服(20.0%)、烫吸(28.6%)(趋势性χ2=440.15,P=0.00)。共用吸毒器具(包括直接共用针管和间接共用稀释液)者HCV感染率显著高于不共用者(χ2=288.92,P=0.00)。有5个以上性伴侣者HCV感染率(86.8%)显著高于有单个性伴侣的感染率(67.7%,χ2=36.41,P=0.00)。MMT门诊患者HCV感染率(85.6%)显著高于强制戒毒人员的感染率(61.7%,χ2=104.72,P=0.00)。肝功能分析显示,该人群丙型肝炎患病率为34.9%。[结论]江苏省吸毒人群的HCV感染率较高,丙型肝炎患病率高,肝功能损害严重,共用注射器及稀释液,多个性伴侣,不使用安全套,以及静脉注射吸毒等高危行为存在普遍,应当采取综合干预措施,控制HCV的传播,降低感染率。[Objective]To investigate the current status of HIV infection,and the relationship of HIV infection with drug-taking methods and characteristics of sexual behavior,and provide scientific basis for formulating intervention methods.[Methods]587 drug users in compulsive addiction treatment centers of Nanjing and 798 drug users in MMT out-patient clinic（OPD） of Wuxi CDC were investigated with unified questionnaires and the venous blood of them were collected to detect anti-HCV and hepatic function.[Results]Among 1 385 drug users,male accounted for 76.6% and female accounted for 23.4%.The positive rate of anti-HCV was 75.5%,and the rate in infection drug users accounted for 88.5% which was significantly higher than that in intramuscular/hypodermic injection drug users（60.0%） ,oral administration drug users（20.0%） ,and singe drug addicts（28.6%） （The χ2 = 440.15,P = 0.00） .The HIV infection rate of drug users sharing injection equipment（syringe and dilution） was significant higher than that of drug users without sharing injection equipment（χ2 = 288.92,P =0.00） .The infection rate of drug users in OPD（85.6%） demonstrated significantly increased than that in compulsive addiction treatment centers（61.7%,χ2 = 104.72,P = 0.00） .The incidence of hepatitis C in these drug users accounted for 34.9% according to the results of the examination of hepatic function.[Conclusion]The study have found that high HCV infection rate,high incidence of hepatitis C,and serious damage of hepatic function.Multi-sexual partners,unprotected sexual behaviors and intravenous injection were widespread among drug users.Comprehensive intervention should be taken to control the transmission of HCV and decrease the infection of HCV.

关 键 词：吸毒人群 HCV 抗-HCV 阳性率 流行病学 

分 类 号：R512.63[医药卫生—内科学]