唐山地区耐药结核分枝杆菌广泛耐药情况的调查  

INVESTIGATION ON THE EXTENSIVE DRUG RESISTANT STATUS OF THE DRUG RESISTANT MYCOBACTERIUM TUBERCULOSIS IN TANGSHAN AREA

作　　者：刘茜[1] 冯福民[1] 王东[1] 郭梅[1] 么作义 李世明[2] 高宝霞[1] 孙永红[1] 

机构地区：[1]华北煤炭医学院预防医学系流行病与卫生统计学科,唐山063000 [2]唐山市结核病医院

出　　处：《现代预防医学》2007年第24期4728-4729,共2页Modern Preventive Medicine

摘　　要：[目的]分析唐山地区耐药MTB对二线药物的耐药情况,初步探讨本地广泛耐药结核病(XDR-TB)在MDR-TB中的比例。[方法]收集唐山地区2004.11.01～2005.10.31结核病患者痰标本,进行分离培养和表型分群,并对4种二线药物应用绝对浓度法进行耐药性检测。[结果]在所分离的102株耐药结核分枝杆菌中,对二线药物的耐药顺位依次为OFL>PAS>Cp>K,30%MDR-TB菌株同时耐4种二线药物,1/3的MDR-TB属于XDR-TB。[结论]唐山地区MTB二线药物耐药情况严重,MDR-TB中的XDR-TB比例过高。[Objective]To analyze the state of drug resistance of MTB to the second-line antituberculosis drugs,and preliminary explore the distribution of extensively drug-resistant tuberculosis in MDR-TB in Tangshan area.[Methods]The sputum samples of patients with TB were cdlected from Nov.1th,2004 to Oct.31th,2005 to conduct isolated wlture and phenotypical classification.The four types of second-line antituberculosis drugs were performed to detect the durg-resistance with the method of the absolute concentration.[Results]Out of the 102 isolating MTB,the drug-resistant MTB to the second-line antituberculosis drugs was by the order as follows：OFL 〉 PAS 〉 Cp 〉 K,as well as 30% of the MDR-TB samples resisted four second-line antituberculosis drugs,and one third of MDR-TB belonged to XDR-TB.[Conclusion]Drug resistance to the second-line antituberculosis drugs is very serious in Tangshan area,and the XDR-TB shows high proportion in the MDR-TB.

关 键 词：结核分枝杆菌 二线药物 广泛耐药结核病 

分 类 号：R378.911[医药卫生—病原生物学]