几种螯合剂解镍致小鼠急性肾毒性作用比较  

COMPARATIVE EFFECTS OF CHELATING AGENTS ON RENAL TOXICITY IN MICE INDUCED BY ACUTE EXPOSURE TO NICKEL

作　　者：谢吉民[1,2] 船越崇行[1,2] 儿岛昭次 

机构地区：[1]镇江医学院 [2]熊本大学药学部

出　　处：《无机化学学报》1997年第2期216-219,共4页Chinese Journal of Inorganic Chemistry

基　　金：日本国佐川先端科学技术振兴财团资助

摘　　要：为寻找镍（Ｎｉ）新型解毒剂，小鼠腹腔注射氯化镍溶液（５ｍｇＮｉ／ｋｇ），观察二乙氨基二硫代甲酸钠（ＤＤＴＣ），二羟乙氨基二硫代甲酸钠（ＤＨＥＤ），Ｎ苯甲基Ｄ葡糖氨基二硫代甲酸钠（ＢＧＤ），ｍｅｓｏ２，３二巯基丁二酸钠（ＤＭＳＡ）及环己烷二胺四乙酸钠（ＣＤＴＡ）等螯合剂对镍致小鼠肾脏毒性的解毒作用。镍染毒引起小鼠肾脏脂质过氧化（ＬＰＯ）和钙、铁及锌浓度增加，血清肌酐及血液尿素氮（ＢＵＮ）升高。镍染毒３０分钟和２４小时后进行各螯合剂治疗（剂量均为４００μｍｏｌ／ｋｇ），ＢＧＤ、ＤＭＳＡ及ＤＤＴＣ可明显抑制上述变化。其中ＢＧＤ解镍毒效果最好、自身毒性最小、对镍致小鼠肾脏毒性有更好的保护作用。Diethyldithiocarbamate (DDTC), dihydroxyethyldithiocarbamate (DHED), N benzyl D glucaminedithiocarbamate (BGD), meso 2,3 dimercapto succinic acid (DMSA) and trans 1,2 cyclohexane diamine N,N,N′,N′ tetraacetic aicd (CDTA) were studied for their protective effects against the renal toxicity in mice induced by acute exposure to nickel (Ni). Mice were injected intraperitoneally with NiCl 2 (5 mg Ni/kg) and 30 min or 24 h later, they were injected intraperitoneally with chelating agents (400 μ mol/kg). Ni injection increased lipid peroxidation (LPO), serum creatinine, blood urea nitrogen (BUN) and concentrations of Ni, Ca, Fe and Zn. BGD, DMSA and DDTC significantly prevented the increase in those changes caused by Ni injection. The results indicated that BGD was more effective chelating agents in protecting against Ni induced renal damage. [WT5”HZ]

关 键 词：镍 解毒剂 BGD CDTA DMSA DHED DDTC 氯化镍 

分 类 号：R979.3[医药卫生—药品]