粤东地区男性不育人群Y染色体无精子因子微缺失的检测及临床应用  

Detection of Y-chromosome Azoospermia Factor Microdeletion of Male Infertility Crowd in East Guangdong and Its Clinical Application

作　　者：林漫燕[1] 蓝柳燕[1] 陈亿长[1] 陈曼丹[1] 

机构地区：[1]汕头大学医学院第二附属医院检验科,广东汕头515041

出　　处：《汕头大学医学院学报》2007年第4期228-229,233,共3页Journal of Shantou University Medical College

摘　　要：目的:探讨粤东地区男性不育人群与Y染色体无精子因子(AZF)微缺失的关系和临床应用。方法:以PCR体外扩增和电泳检测技术检测粤东地区男性不育人群的Y染色体AZF微缺失情况。结果:实验组(46例)8例Y染色体AZF微缺失,对照组(10例)Y染色体AZF15个位点无缺失。结论:Y染色体AZF微缺失是造成男性无精子症或严重少精子症的病因之一,对男性不育人群进行Y染色体AZF微缺失检测是十分必要的。Objective： To find out the relationship between the male infertility and the Y-chromosome azoospermia factor（ AZF）microdeletion and its clinical application in east Guangdong. Methods： The Y-chromosome AZF microdeletion of male infertility crowd in east Guangdong was detected by PCR multiplex technique and the electrophoresis technology. Results： Eight cases with Y-chromosome AZF microdeletion were detected in the experimental group（46 patients）, 15 testing sites of Y-chromosome AZF had no deletion in the control group（ 10 patients）. Conclusion： Y-chromosome AZF microdeletion is one of the causes which result in azoospermia or severe oligozoospermia. The detection of Y-chromosome AZF microdeletion is necessary for the male infertility crowd.

关 键 词：Y染色体 无精子因子 男性不育 

分 类 号：R373[医药卫生—病原生物学]