母亲妊娠合并糖尿病对新生儿血糖、胰岛素、胰岛素样生长因子-1的影响  

Effect of gestational diabetes mellitus on blood glucose,insulin,insulin-like growth factor Ⅰ in neonates

作　　者：崔丽君[1] 韩丽萍[1] 乔彦霞[1] 李彤娟[1] 

机构地区：[1]河北省石家庄市第四医院,050011

出　　处：《中国妇幼保健》2007年第36期5198-5199,共2页Maternal and Child Health Care of China

摘　　要：目的:研究母亲妊娠合并糖尿病对新生儿血糖、胰岛素、胰岛素样生长因子-1(IGF-1)的影响。方法:29例母亲妊娠合并糖尿病的新生儿及20例健康新生儿均于生后1h内测空腹血糖,并采脐血用放射免疫法测定胰岛素、IGF-1水平。结果:母亲妊娠合并糖尿病其新生儿生后血糖水平低于对照组(P<0.05);胰岛素、IGF-1水平高于对照组(P<0.05),血糖水平与IGF-1呈负相关(r=-0.432,P<0.05)。结论:母亲妊娠合并糖尿病会导致新生儿生后血糖水平的降低,胰岛素、IGF-1水平的升高,二者共同参与血糖的调节,对这部分新生儿应做好血糖监测,防止低血糖的发生。Objective： To explore the effect of gestational diabetes mellitus on blood glucose, insulin, insulin -like growth factor （IGF） Ⅰ in neonate. Methods： The blood glucose were measured in 29 neonates with maternal gestational diabetes mellitus and 20 health neonates after delivery in 1 hour. The insulin and IGF - Ⅰ in umbilical serum were measured by radioimmunoassay. Results： The blood glucose levels in neonates with maternal gestational diabetes mellitus were significantly lower than that in control group after delivery （P 〈 0. 05） . The insulin and IGF - Ⅰ levels were significantly higher than those in control group （ P 〈 0. 05 ） and the blood glucose was negatively correlated with the IGF- Ⅰ. Conclusion： Maternal gestational diabetes mellitus could cause a lower level of blood glucose and higher levels of insulin, IGF -Ⅰ in neonate after delivery. Both the insulin and IGF -Ⅰ might regulate the blood glucose. The blood glucose levels in these neonates should be monitored to prevent low blood glucose.

关 键 词：妊娠期糖尿病 新生儿 血糖 胰岛素 胰岛素样生长因子-1 

分 类 号：R587.2[医药卫生—内分泌]