小鼠早期胚胎肢体发育中的视黄酸诱导的视黄酸代谢  

Retinoic acid induced retinoic acid degradation in the early limb development of mouse

作　　者：苏循瑞[1] 高元奇[2] 胡建[1] 赵显玲[1] 

机构地区：[1]东北师范大学生命科学学院,吉林长春130024 [2]吉林大学医学部基础医学院,吉林长春130021

出　　处：《分子科学学报》2007年第6期390-393,共4页Journal of Molecular Science

基　　金：国家自然科学基金资助项目(30470903);留学回国人员启动基金资助项目

摘　　要：给怀孕10 d的小鼠胃灌流视黄酸(100 mgRA/kg体重)6和24 h后,对视黄酸合成酶基因Raldh2和代谢酶基因Cyp26a1,Cyp26b1在胚胎肢体的表达进行了分析.Cyp26a1和Cyp26b1在灌流6 h,表达增加;灌流24 h,表达恢复到正常水平.Raldh2在此时间段表达降低.这些结果提示:在小鼠早期胚胎肢体发育中,存在视黄酸诱导的视黄酸代谢.The expression of Raldh2, Cyp26a1 and Cyp26b1 in the limb of mouse embryo was examined after the pregnant mouse at E10 was treated by retinoic acid （RA） （m（RA）/m（body weight）100 = mg/kg） ： by garage for 6 and 24 h. The expression of Cyp26a1 and Cyp26b1 increased after 6 h RA supplement, and returned to normal level after 24 h RA supplement. The expression of Raldh2 decreased during RA treatment. These results indicate that retinoic acid induced degradation of retinoic acid exists in the early limb development of mouse.

关 键 词：视黄酸 肢体发育 视黄酸合成 视黄酸代谢 

分 类 号：Q81[生物学—生物工程]