三氯乙烯药疹样皮炎患者体内补体等变化情况观察  

Research on the changes of complements in patients of dermatitis medicamentosa-like induced by trichloroethylene

作　　者：越飞[1] 曾泽明[1] 陈润涛[1] 李森华[1] 黄汉林[1] 

机构地区：[1]广东省职业病防治院,广东广州510300

出　　处：《中国职业医学》2007年第6期448-449,共2页China Occupational Medicine

基　　金：国家自然科学基金项目(30500401);广东省自然科学基金项目(5003556)

摘　　要：目的探索三氯乙烯药疹样皮炎发病机制。方法对三氯乙烯药疹样皮炎患者部分免疫相关血液生化指标进行分析,观察各指标随病程变化情况。收集13例确诊三氯乙烯药疹样皮炎患者入院时和治疗1个月后血液生化检查中部分免疫相关指标(包括IgG、IgA、IgM、C3、C4等),比较治疗前后这些指标是否发生变化。结果治疗前C3含量和IgM含量明显低于治疗后(近似正常状态)(0.846vs1.402,0.818vs0.949,均P<0.05),其他指标差异无显著性。结论三氯乙烯药疹样皮炎患者病程中可能存在补体活化,从而引起脏器损伤。Objective To explore the mechanism of dermatitis medicamentosa-like of trichloroethylene（DMLT）. Methods Totally 13 DMLT patients were observed. Some indexes related to immunity in these patients such as IgG,IgA,IgM,C3 and C4 were tested before and 1 month after med/cal treatment, then the resuhs were compared. Results Compared with the results after treatment, the concentrations of C3 and IgM in serum before treatment were significantly at low levels （0. 846 vs 1. 402,0. 818 vs 0. 949,P 〈 0. 05）, but other indexes had no significant changes. Conclusion There may have been complement-activation in DMLT, and the activated-complement induces organ injury.

关 键 词：三氯乙烯 皮炎 补体 

分 类 号：R135.1[医药卫生—劳动卫生]