硫酸铝钾对小鼠胚胎中脑细胞增殖和分化的影响  

Effects of aluminum potassium sulfate on proliferation and differentiation of mouse embryo midbrain cells

作　　者：陈雅[1] 张本忠[1] 

机构地区：[1]三峡大学医学院,湖北宜昌443002

出　　处：《中国职业医学》2007年第6期458-459,共2页China Occupational Medicine

摘　　要：目的研究硫酸铝钾对胎鼠中脑细胞增殖和分化的影响。方法采用细胞微团培养法,观察不同浓度(0～100μmol/L)的硫酸铝钾对胎鼠中脑细胞增殖和分化的影响。结果硫酸铝钾对离体培养的中脑细胞的增殖和分化均有抑制作用,其半数增殖抑制浓度(IP50)为45.03μmol/L、半数分化抑制浓度(ID50)为3.92μmol/L,IP50/ID50=11.5。结论硫酸铝钾对细胞分化有特异抑制作用。Objective To study the effect of aluminum potassium sulfate [KAI（SO4）2] on proliferation and differentiation in mouse embryo midbrain cells. Methods The micromass culture method was used to observe the effect of KAl（SO4） 2 at different concentrations （0 ～ 100 μmol/L）. Results The proliferation and differentiation of midbrain cells were inhibited by KAl （ SO4 ） 2, and the concentrations of inhibition by 50% were 45.03 μ mol/L （ IP50 ） and 3.92 μmol/L （ ID50 ）, respectively. The ratio of IP50 and ID50 was 11.5. Conclusion KAI（SO4）2 could be a specific inhibitor of cells differentiation.

关 键 词：硫酸铝钾 小鼠胚胎 中脑细胞 增值 分化 

分 类 号：R135.1[医药卫生—劳动卫生]