嗅三针电刺激对急性局灶性脑缺血再灌注大鼠大脑皮层NO ET LPO的影响  

Investigating NO ET LPO Levels of Cerebral Cortex of Acute Focal Cerebral Ischemia Reperfusion Rat by Electro-Stimulating XIU Three Needles

作　　者：牛文民[1] 刘智斌[1] 

机构地区：[1]陕西中医学院,陕西咸阳712083

出　　处：《辽宁中医杂志》2007年第12期1808-1809,共2页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:探索嗅三针电刺激对急性局灶性脑缺血再灌注大鼠大脑皮层保护作用的机理。方法:采用嗅三针电刺激治疗急性局灶性脑缺血再灌注大鼠并测定大脑皮层一氧化氮(NO)、内皮素(ET)及脂质过氧化物(LPO)含量。结果:模型组大脑皮层NO、ET和LPO含量检测结果与对照组相比较,均有极显著差异(P<0.01);嗅三针电刺激治疗后,大脑皮层NO、ET和LPO含量检测结果均有明显改善,与模型组相比较有极显著差异(P<0.01)。结论:嗅三针电刺激对急性局灶性脑缺血再灌注大鼠所引发的大脑皮层损伤具有确切的保护作用,其作用机理与改善血液循环和拮抗过氧化损伤密切相关。Objective： To explore the protective effect and its mechanism of electro- stimulating XIU three needles on cerebral cortex of acute focal cerebral iscbemia - repeffusion SD rats. Methods ： Using electro - stimulating XIU three needles to treat the acute focal cerebral ischemia -repeffusion SD rats combined with examining the levels of nitric oxlde（NO） ,endothelin （ET） and lipid peroxide （LPO） in cerebral cortex. Results： Compared with control group,the changes of NO,ET and LPO of cerebral cortex in model group are significant （ P 〈 0.01 ） ; After treatment of electro - stimulating XIU three needles, the results of the levels of NO, ET and LPO of cerebral cortex are greatly improved, compared with model group （ P 〈 0.01 ）. Conclusion： Electro- stimulating XIU three needles had an definite protective effect on the damage of cerebral cortex made by acute focal cerebral ischemia - repeffusion. Its mechanism of therapeutical effect of electro - stimulating XIU three needles may be related to improved blood circulation and antioxidation.

关 键 词：脑缺血再灌注 大脑皮层 嗅三针 电刺激 抗氧化 

分 类 号：R245.97[医药卫生—针灸推拿学]