囊立消对大鼠癫痫模型脑组织中TNF-α和IL-1β含量的影响  

A Study of TNF-α and IL-1β in Epilepsy Rat's Brain Treated with Nanglixiao

作　　者：吴勃岩[1] 徐绍娜[1] 祝司霞 郭艳莹 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]四川攀枝花医学院,四川攀枝花617000 [3]哈尔滨市妇幼保健院,黑龙江哈尔滨150010

出　　处：《辽宁中医杂志》2007年第12期1818-1819,共2页Liaoning Journal of Traditional Chinese Medicine

基　　金：黑龙江省自然科学基金资助项目(C2004-53)

摘　　要：目的:探讨囊立消的抗癫痫作用。方法:背部皮下注射美解眠后大鼠痫性发作,观察大鼠的行为表现,采用放射免疫法检测大鼠癫痫模型脑组织中TNF-α和IL-1β的含量。结果:该方药可使癫痫大鼠发作程度减轻和发作潜伏期延长;使癫痫大鼠脑内TNF-α和IL-1β含量明显降低,与模型对照组比较差异显著(P<0.05)。结论:囊立消可有效地改善癫痫大鼠的行为表现,囊立消具有抗癫痫作用。Objective： To explore the anti -epilepsy mechanism of Nanglixiao. Method： To observe the behavior symptoms of epilepsy rat after injected Bemegride endermic. Measure the content of TNF - α and IL - 1β in brain of epilepsy rat model by radio - immunity method. Results： Nanglixiao can remarkably reduce the behavior symptoms of epilepsy and prolong the latent period. The medical can also decrease the content of TNF - α and IL - 1β （ P 〈 0.05） in contrast of the model. Conclusion ： Nanglixiao can effectively improve behavior symptoms of epilepsy rat model. Nanglixiao has the anti - epilepsy effect.

关 键 词：囊立消 癫痫模型 TNF—α IL-1Β 

分 类 号：R285.5[医药卫生—中药学]