医药中间体丙酮缩氨基脲合成研究  

Study on Synthesis of a Medicine Intermediate-Acetone Semicarbazone

作　　者：杨琼[1] 周丹丹[1] 

机构地区：[1]宝鸡文理学院化学化工系,陕西宝鸡721000

出　　处：《贵州化工》2007年第6期3-6,共4页Guizhou Chemical Industry

摘　　要：以盐酸氨基脲、丙酮为原料,直接反应合成了医药中间体丙酮缩氨基脲;分别研究了反应温度、反应时间、原料配比等条件对合成反应的影响,从而确定了最佳工艺条件;用该方法合成丙酮缩氨基脲的最佳工艺条件是:盐酸氨基脲和丙酮反应温度为52℃;反应时间为1.5h;n(盐酸氨基脲):n(丙酮)=1:7;丙酮缩氨基脲的收率达到63.98%。Acetone semicarbazone was directly synthesized from semicarbaxide hydrochloride and acetone. The effect ofreaction temperature , reaction time , materials ratio on the synthesis was studied. The properreaction conditions were as follows ： the reaction temperature for semicarbaxide hydrochloride and acetone was 52℃ ;the reactiontime was 1.5 h ; the molar ratio of semicarbaxide hydrochloride： acetone was 1：7, The yield of product was 63. 89%.

关 键 词：丙酮缩氨基脲 盐酸氨基脲 丙酮 水合肼 

分 类 号：TQ241.33[化学工程—有机化工]