黄芪注射液对高血压病患者炎症介质的影响  

Effects of Injectio Radix Astragali on inflammatory mediators in essential hypertension

作　　者：张小卫[1] 余静[1] 常鹏[1] 李秀丽[1] 郭雪娅[1] 赵锋[1] 

机构地区：[1]兰州大学第二医院心内科,甘肃兰州730030

出　　处：《兰州大学学报（医学版）》2007年第4期47-49,共3页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省自然科学基金(ZS031-A25-054-E);甘肃省科学事业费(QS041-C33-17)资助项目。

摘　　要：目的观察黄芪注射液对高血压病患者炎症介质的影响。方法采用平行随机对照区组设计,高血压病患者87例随机分为两组(黄芪组及常规治疗组),对照组健康人45例。放免法测定各组中血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素1β(IL-1β)及白介素-6(IL-6)的含量。黄芪组常规降压加黄芪注射液后14 d再测定上述指标,常规治疗组经常规降压14 d后测定上述指标。结果高血压病患者较健康人比较血清hs-CRP,血浆TNF-α、IL-1β和IL-6均升高(P<0.01)。黄芪注射液治疗后高血压病患者血清hs-CRP、TNF-α、IL-1β和IL-6降低(P<0.01或<0.05)。结论黄芪注射液可在较短治疗周期内降低高血压病患者血清炎症介质。Objective To investigate the effects of Injectio Radix Astragali （Huangqi） on inflammatory mediators in essential hypertension （EH）. Methods Paralleling randomized control block design was adopted to randomize 87 EH patients into two groups （Radix Astragali group and ordinary management group）, and 45 healthy people, were used as normal controls. The levels of serum high sensitive C-reactive protein （hs-CRP）, plasma tumor necrosis factor-α （TNF-α）, interleukin-1β （IL-1β） and interleukin-6 （IL-6） were detected respectively by radioimmunoassay before and after Injectio Radix Astragali treatment. All of the indexes were detected in controls after 14 days of treatment. Results The levels of serum hs-CRP, plasma TNF-α, IL-1β and IL-6 were higher （P 〈0.05） in EH group than in normal control group. Injectio Radix Astragali could decrease the levels of serum hs-CRP, TNF-α, IL-1β and IL-6 in EH groups （all P 〈0.01 or 〈0.05）. Conclusion Injectio Radix Astragali may decrease the inflammatory mediators in essential hypertension.

关 键 词：黄芪注射液 高血压病 炎症介质 

分 类 号：R459.7[医药卫生—急诊医学]