妊娠期糖尿病的发病机制  

The Pathogenesis of Gestational Diabetes Mellitus

作　　者：贺瑜[1] 梁敏[1] 

机构地区：[1]广西医科大学第一附属医院内分泌科,南宁530021

出　　处：《医学综述》2007年第24期1982-1984,共3页Medical Recapitulate

摘　　要：妊娠期糖尿病(GDM)为糖尿病的一种特殊类型,对母亲和胎儿都有不利影响。GDM孕妇存在比正常孕妇更强烈的胰岛素抵抗,并且胰岛β细胞功能存在缺陷。C反应蛋白、白细胞介素6等炎性因子参与了GDM孕妇慢性炎症的发生。免疫失衡造成细胞毒性因子的释放增加,增加了GDM发生的风险。人类白细胞抗原分子作为免疫调节分子,可能与GDM有一定的关系,GDM孕妇某些人类白细胞抗原基因型频率是增加的。Gestational diabetes mellitus（GDM） is a special type of diabetes mellitus, which has adverse effect on the mother in pregnancy and their infants. Pregnant mother with GDM had more severe insulin resis- tance than that of healthy pregnant mother besides their functional defect in beta Cell Of islet. Inflammatory factors including C reactive protein, interleukin 6 and so on took part in the gen^s of chronic inflammatory of pre4nant mother with GDM. Increased releasing of cytotoxic factor resulting from immune unbaulance had increased the risk of GDM. As one kind of immune regulatory molecules, HLA molecules maybe related to GDM inn some certain. There is increased frequency of HLA genotype in pregnant mother with GDM.

关 键 词：妊娠期糖尿病 发病机制 胰岛素抵抗 

分 类 号：R271.41[医药卫生—中医妇科学]