缬沙坦对自体移植静脉内膜Fas、FasL表达的影响  

Effect of valsartan on expression of Fas and FasL on neointima in rabbit autogenous vein graft

作　　者：仲崇俊[1] 蒋庚西[1] 

机构地区：[1]江苏省南通市第一人民医院南通大学第二附属医院心胸外科,南通226001

出　　处：《南通大学学报（医学版）》2007年第5期329-331,共3页Journal of Nantong University(Medical sciences)

基　　金：南通市社会发展项目资助(S50023)

摘　　要：目的:观察缬沙坦对兔颈部自体移植静脉内膜增生、Fas、FasL表达的影响,探讨血管紧张素Ⅱ1型受体(AT1)拮抗剂干预移植静脉再狭窄的作用和机制。方法:雄性新西兰大白兔20只行颈部自体静脉移植手术,对照组予普通饲料饲养,缬沙坦组予普通饲料+缬沙坦饲养,4周后取出静脉移植物行血管形态学检查,免疫组化方法检测Fas、FasL表达情况。结果:对比对照组,缬沙坦组移植静脉新生内膜厚度及面积明显减轻(P<0.01),Fas、FasL表达增加(P<0.05)。结论:缬沙坦可以显著抑制兔自体移植静脉新生内膜的形成,其机制与促进内膜Fas、FasL的表达、进而促进血管平滑肌细胞凋亡有关。Objective ：To investigate the effect of Valsartan on intimal proliferation, and the expression of Fas and FasL on neointima,and to explain its mechanism of preventing restenosis in rabbit autogenous vein graft. Methods：20 male New Zealand White rabbits were randomly divided into two groups. The right external jugular veins of 20 rabbits were interposed between ipsolateral common carotid arteries. The control group was fed with common diet, and the treatment group was fed with common diet and valsartan （10mg.kg^-1·d^-1） . At the end of 4 weeks, the vein grafts were harvested and examined with pathologic and morphologic analysis. Fas and FasL on neointima were analyzed with immunohistochemical method. Results： Compared with the control group, the neointimal thickness and size were reduced in the treatment group （P〈0.01）. The expression of Fas and FasL in the treatment group was significantly higher than that in the control group （P〈0.05）. Conclusion ： Valsartan could significantly prevent intimal hyperplasia in rabbit autogenous vein graft. The mechanism possibly invloved in its increasing the expression of Fas and FasL, and thus increasing the apoptosis of VSMC.

关 键 词：血管紧张素Ⅱ1型受体拮抗剂 自体移植静脉 FAS FAS配体 

分 类 号：R654.3[医药卫生—外科学]