2450MHz微波对受照小鼠粒系造血相关指标的影响  

Effect of 2450 MHz Microwave on Haematogenous of Granulocytic Series of Mice

作　　者：程康[1] 王海昌[1] 任东青[2] 陈永斌[2] 张杰[2] 张发科[2] 曾桂英[2] 

机构地区：[1]第四军医大学西京医院心血管内科,陕西西安市710033 [2]第四军医大学军事预防医学系放射医学教研室,陕西西安市710032

出　　处：《中国康复理论与实践》2007年第12期1134-1136,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家自然科学基金资助项目(No30570447)

摘　　要：目的观察2450MHz微波对小鼠外周血白细胞数和骨髓粒系造血的影响。方法选用频率为2450MHz、功率密度为10mW/cm2的微波对BALB/c小鼠进行全身辐照,于辐照后不同时间活杀,分别测定脾指数、外周血白细胞数、骨髓有核细胞数、细胞周期和粒细胞-巨细胞集落形成单位(GM-CFU)形成能力的变化。结果随着微波辐照时间的延长,外周血白细胞数先升高后降低;微波辐照后骨髓有核细胞数呈持续性降低,而骨髓细胞GM-CFU生成能力却增强;2450MHz10mW/cm2微波辐照可加速骨髓有核细胞从G1期进入G2期和S期。结论低功率密度的2450MHz微波短期辐照对粒系造血具有明显刺激作用,但随辐照时间的延长,有核细胞数减少。Objective To observe the effect of 2450 MHz microwave on the white blood cells （WBC） and haematogenous of granulocytic series of mice. Methods The whole body of BALB/c mice were exposure to 2450 MHz power density （10 mW/cm^2） microwave, and the mice were killed at different times after exposure, to determine the changes of spleen/body ratio, peripheral blood WBC, number of marrow nucleus cells, cell cycle and form ability of GM-CFU （granule and macrophage-clone forming unit）. Results The number of peripheral blood WBC increased at first and then reduced with the exposure time prolonged. Number of marrow nucleus cells kept decreasing after microwave exposure, otherwise, form ability of GM-CFU of marrow cells increased. Exposure to 2450 MHz 10 mV/cm^2 microwave might speed up marrow nucleus cell passed from G1 period to G2 and S periods. Conclusion Low frequency of 2450 MHz microwave exposure has significant stimulate function on granule cell system, but with the time prolong, number of nucleus cells decreased.

关 键 词：微波 白细胞 造血 细胞周期 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]