药动学-药效学结合模型的研究进展及在新药研发中的应用  

Recent advances in pharmacokinetic-pharmacodynamic modeling and its applications in drug research and development

作　　者：柳晓泉[1] 陈渊成[1] 郝琨[1] 曹彦光[1] 余丹[1] 

机构地区：[1]中国药科大学药物代谢与动力学研究中心,南京210009

出　　处：《中国药科大学学报》2007年第6期481-488,共8页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.30772609)

摘　　要：药动学-药效学(PK-PD)结合模型是综合研究药物在体内的动态变化过程与其药效消长之间关系的一种有力工具,它借助数学方法定量表述浓度(或剂量)、时间和效应三者之间的内在关系,对药物的研究开发及合理使用具有普遍的指导意义。PK-PD模型可按药动学与药效学联结方式的不同分成4种基本类型。近年来,神经网络技术、最优设计理论推动了具有多成分多靶点作用特征的PK-PD模型的发展。本文最后重点介绍了PK-PD模型在新药研发的临床前和临床阶段的应用以及当前研究热点,并对今后的发展趋势进行展望。Pharmacokinetic-pharmacodynamic （PK-PD） modeling is a powerful tool which links pharmacokinetics and pharmacodynamics and describes the inter-relationship among dosage or concentration, time and response, thereby gaining ever-increasing applications in the drug development process and dosage optimization. According to the manner in which the measured pharmacokinetic and pharmacodynamic data are related to each other, PK-PD models can be classified into four kinds of basic models. In recent years, the applications of neural networks technology and optimal design theory in PK-PD study promote the development of PK-PD models with multicomponents and multitargets. Finally, this paper presents the applications of PK-PD modeling in the pre-clinical and clinical stages of drug research and development intensively as well as its current hot spot and tendency.

关 键 词：药动学 药效学 模型 药物研发 

分 类 号：R96[医药卫生—药理学]