银屑病患者外周血TNF-α、IL-6水平的变化及意义  

Changes of Serum TNF-α and IL-6 Levels in Patients with Psoriasis and Their Clinical Significance

作　　者：刘元林[1] 徐文[1] 鲁祖清[1] 

机构地区：[1]海军总医院皮肤科,北京100037

出　　处：《海军总医院学报》2007年第4期222-223,共2页Journal of Naval General Hospital of PLA

摘　　要：目的探讨肿瘤坏死因子-α、白介素-6与银屑病发病之间的联系及其意义。方法采用酶联免疫吸附测定法测定46例银屑病患者治疗前后外周血肿瘤坏死因子-α、白介素-6水平的变化,并与银屑病皮损面积及严重度指数评分做相关性分析。结果①银屑病患者肿瘤坏死因子-α、白介素-6水平显著高于正常对照组(P<0.001),且两者间呈正相关;②治疗后肿瘤坏死因子-α、白介素-6水平明显下降(P<0.001),但仍高于正常对照组(P<0.01);③肿瘤坏死因子-α、白介素-6与银屑病皮损面积及严重度指数评分均呈正相关(P<0.001)。结论肿瘤坏死因子-α、白介素-6可能与银屑病免疫学发病机制有关,经治疗后肿瘤坏死因子-α、白介素-6水平明显下降,提示免疫调节可能有助于银屑病治疗。Objective To explore the correlation between TNF-α and IL-6 and the pathogenesis of psoriasis. Methods Serum levels of TNF-α and IL-6 were measured by ELISA in 46 patients with psoriasis before and after treatment. The correlation between TNF-α and IL-6 PASI in the patients was also analyzed. Results ①The Serum levels of TNF-α and IL-6 were significantly higher in patients with psoriasis than those of controls（P〈0. 001）. ②After treatment the levels of TNF-α and IL-6 decreased significantly（P〈0. 001）, but were still higher than those of controls（P〈0.01）. The positive correlation was found between TNF-α and IL-6.③Serum TNF-α and IL-6 levels in these patients had a positive correlation with PASI（P〈0. 001）. Conclusion TNF-α and IL-6 might play a role in the immunopathogenesis of psoriasis. After treatment the serum levels of TNF-α and IL-6 remarkably decreased, which indicats that immune-regulation may be heplful for treatment of psoriasis.

关 键 词：银屑病 肿瘤坏死因子-Α 白介素-6 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]