拜心通对高血压左心室肥厚患者血浆P物质及左心室质量指数的影响  

Influence of Adalat GITS on left ventricular mass index and substance P in hypertension patients with left ventricular hypertrophy

作　　者：郭文涛[1,2,3] 崔天祥[1,2,3] 黄振文 

机构地区：[1]中国人民解放军371医院内科 [2]河南医科大学第二附属医院内科 [3]河南医科大学第一附属医院内科

出　　处：《河南医科大学学报》1997年第2期1-3,共3页Journal of Henan Medical University

基　　金：河南省科技攻关项目

摘　　要：为了探讨拜心通对高血压左心室肥厚（ＬＶＨ）患者的左心室质量指数（ＬＶＭＩ）及血浆Ｐ物质（ＳＰ）的影响，选择了２６例高血压伴ＬＶＨ患者每ｄ口服拜心通３０ｍｇ，治疗１２周。结果：治疗后ＬＶＭＩ平均降低２９．０３ｇ·ｍ－２，下降幅度为２０．６４％；治疗前后ＬＶＭＩ差异有显著性（Ｐ＜０．００１）；血浆ＳＰ浓度治疗前后无显著性差异（Ｐ＞０．０５）。结果提示：拜心通能够逆转ＬＶＨ，对血浆ＳＰ浓度无明显影响。Twenty white adult rabbits of the same race were implanted with fetal brain tissue and its tissue culture of 10 to 13 days fetus weighting 0.3 to 0.5 gram.It indicated that the graft was able to live,grow and reproduce in the living body.Hole drilling was performed on the frontal and temporal bones or frontal,temporal and parietal bones of 6 patients with cerebral dysplasia due to various causes.The transplanting grafts were brain tissue cultures of 4 month old fetus obtained from voluntary gravida by using induced labor with water sac.Every patient received 8 to 12 gram of transplant.The results showed that symptoms of 5 cases improved on the operating days.Followed up of 1.5 to 2 years,showed that the epilepsy of 3 cases stopped attacking,the muscle tension of 4 cases was much lower than that before operation,its function of limbs was much better,the intelligence quotient(IQ) increased by 38 to 51 points,slow wave decreased in electroencephalogram (EEG),epilepsy wave disappeared and the sensory evoked potential (SEP),motion evoked potential (MEP),brain stem auditory evoked potential (BEAP),visual evoked potential (VEP) were improved to various degrees.Only one patient′s clinical manifestation didn′t improved significantly.The total efficiency was 83%.It was concluded that the treatment of cerebral dysplasia with fetal brain transplant was effective.

关 键 词：高血压 左心室肥厚 P物质 药物疗法 拜心通 

分 类 号：R541.305[医药卫生—心血管疾病]