碘克沙醇对行介入治疗的老年冠心病患者肾功能的影响  

Effect of iodixanol on renal function in old coronary heart patients disease treated with:analysis of 1656 cases percutaneous coronary intervention

作　　者：李菲[1] 韩雅玲[1] 张进[1] 彭岩松[1] 

机构地区：[1]沈阳军区总医院全军心血管病研究所心血管内科,沈阳市110016

出　　处：《中华老年多器官疾病杂志》2007年第6期407-408,共2页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：目的观察碘克沙醇(威视派克)在老年冠心病肾功能不全介入治疗患者中的应用,探讨其对行介入治疗的老年冠心病患者的有效性和安全性。方法选取2005年1月至2006年3月行经皮冠脉介入治疗的老年肾功能不全冠心病患者1656例,分为对照组(碘普罗胺,优维显)828例,观察组(威视派克)828例,分别于术前及术后3d监测患者的血清肌酐(Scr)浓度,计算其术后3dScr的升高幅度及引起造影剂肾病的发生率。结果对照组术后3dScr值明显高于术前〔(178±32)μmol/Lvs(156±26)μmol/L,P<0.05〕,造影剂肾病发生率为26.3%;观察组则没有明显增加,分别为(164±31)μmol/Lvs(160±28)μmol/L(P>0.05),造影剂肾病发生率为3.2%,明显低于对照组。结论威视派克用于行介入治疗的老年冠心病患者是安全有效的。Objective To evaluate the effectiveness and safety of iodixanol in old patients with coronary heart disease（CHD） complicated with renal insufficiency treated with percutaneous coronary intervention（PCI）. Methods From January 2005 to March 2006, 1656 old CHD patients complicated with renal insufficiency were divided into two groups, control group （iopromide group） included 828 patients and test group（iodixanol group） 828 patients. Serum creatinine （Scr） was measured before operation and 3 d after operation. The difference and the rate of contrast-induced nephropathy （CIN） were calculated. Results The value of Scr on d 3 after operation was significantly higher than the preoperative value [（178±32） vs （156±26）μmol/L,P〈0. 053 and the rate of CIN was 26.3 % in the control group, while in the test group, the value of Scr on d 3 after operation was not significantly higher than the preoperative value [（164±31） vs （160±28）μmol/L,P〉0.05]and the rate of CIN was 3.2% which was significantly lower than the control group. Conclusion Application of iodixanol to old CHD patients was safe and effective.

关 键 词：威视派克 经皮冠状动脉介入 肾病 造影剂 

分 类 号：R541.4[医药卫生—心血管疾病]