α1受体阻滞剂诱导前列腺细胞凋亡的临床意义  

Clinical significance of apoptosis of human prostatic cells induced by α1-adrenoreceptor antagonists

作　　者：汤平[1] 谢克基[1] 钟惟德[1] 胡建波[1] 魏鸿蔼[1] 王良圣[1] 

机构地区：[1]广州医学院附属广州市第一人民医院泌尿外科,510180

出　　处：《现代临床医学生物工程学杂志》2007年第2期91-93,共3页Journal of Modern Clinical Medical Bioengineering

摘　　要：目的探讨α1受体（α1-AR）阻滞剂诱导前列腺细胞凋亡的临床意义。方法取穿刺或手术切除的良性前列腺组织。根据服用α1-AR阻滞剂（特拉唑嗪或多沙唑嗪）时间长短分组：A组（对照组，未服药物者）；B组（服药1～3个月）；C组（服药3～6个月）；D组（服药6～12个月）。原位凋亡法（TUNEL）检测各组前列腺细胞凋亡的情况。分析细胞凋亡情况及其与国际前列腺症状评分（IPSS）、生活质量评分（QOL）、最大尿流率（MUF）改善的关系。结果B、C、D组前列腺细胞凋亡率（AI）分别为（1．5±0．8）％、（2．3±1．2）％、（2．4±1．1）％，较A组（0．8±0．5）％明显增高（P〈0，01）。C组与B组的AI差异有统计学意义（P〈0．05）；D组与c组的AI差异无统计学意义。B、C、D组IPSS的改善为（5，0±3．3）、（8．0±3．5）、（9．0±1．8）；QOL的改善为（2．0±0．9）、（3，0±1．6）、（3．0±1，9）分；MUF的改善为（3．0±1．2）、（5．0±3，2）、（6．0±1，7）ml／s；均较A组的改善明显增高（P〈0．01）。C组IPSS、QOL、MUF的改善均较B组明显增高（P〈0．05）；D组IPSS、QOL、MUF的改善与C组比较差异无统计学意义（P〉0.05）。前列腺细胞的AI与患者IPSS、QOL、MUF的改善呈正相关（r=0.361，0.289，0．412，P均〈0．01）。结论α1．AR阻滞剂诱导前列腺细胞凋亡与下尿路症状改善相关，可能为药物治疗良性前列腺增生（BPH）机制之一。Objective To investigate the clinical significance of apoptosis of human prostatic cells induced by α1-adrenoreceptor（ α1-AR） antagonists. Methods The benign prostatic tissues were taken from needle biopsies and urological operations. The patients who used or not used α1-AR antagonists （terazosin or doxazosln） in the treatment of symptomatic benign prostatic hyperplasla（BPH） were divided into four groups： A group （ without α1 -AR antagonists, control group ）, B group （ medication duration for 1 - 3 months ）, C group （for 3 -6 months）, D group （for 6 - 12 months）. The apoptosis of the prostatic cells was assessed by terminal deoxynucleotidyl transferase-mediated hapten-labeled deoxy-uracil triphosphate nick end labeling （TUNEL） assay. The patients treated with α1-AR antagonists were determined retrospectively by the international prostatic symptom score （ IPSS ）, maximum urinary flowrate （ MUF ）, quality of life （QOL） and compared after the treatment. Correlation between the apoptosis index（AI） of prostatic cells and the change of IPSS, QOL, MUF was examined. Results The AI of B, C, D group was （ 1.5 ± 0.8 ） %, （ 2.3 ± 1.2 ） %, （2.4 ± 1. 1 ）% respectively. When compared with that of A group （0. 8 ± 0.5% ）, the differences were significant（all P〈0.01）[ The AI in C group was higher than that in B group （P〈0.01）. The AI in D group was not significant compared with that in C group（ P 〉 0.05 ）. The improvement of IPSS, QOL, MUF was （5.0 ±3.3） score,（2.0 ±0.9）score,（3.0 ± 1.2） ml/s in B group; （8.0 ±3.5）score, （3.0 ± 1.6）score, （ 5.0 ± 3.2 ） ml/s in C group and （ 9.0 ± 1.8 ） score, （ 3.0 ± 1.9 ） score, （ 6.0 ± 1.7 ） ml/s in D group. The results showed much higher than those of A group（P 〈0.01 ）. The improvement of IPSS ,QOL,MUF in C group was significantly higher than that in B group （ P 〈 0.01 ）, but it was not significant between C group and D gronp（P 〉 0. 05 ）. Th

关 键 词：肾上腺素能受体 良性前列腺增生 凋亡 

分 类 号：R697.32[医药卫生—泌尿科学]