心肌肌钙蛋白I和肌钙蛋白T检测在病毒性心肌炎诊断中的应用  

Applications of cardic troponin T and cardic troponin I in diagnosing viral myocarditis

作　　者：李志平 罗阳[2] 张雪[2] 府伟灵[2] 

机构地区：[1]山西省高平市人民医院心血管内科,048400 [2]第三军医大学西南医院检验科,重庆400038

出　　处：《重庆医学》2007年第24期2547-2549,共3页Chongqing medicine

摘　　要：目的探讨肌钙蛋白I(cTnI)和肌钙蛋白T(cTnT)在病毒性心肌炎(VMC)的诊断及病情观察方面的价值。方法对78例病毒性心肌炎患者进行入院后1、2、3周及2个月cTnT和心肌酶谱的动态监测;cTnT、cTnI与心电图(ECG)、及病程关系的研究。结果急性病毒性心肌炎患者在各检测期内血清cTnT的阳性率(73.8%)和cTnI的阳性率(66.7%)显著高于心肌酶谱各项目(P<0.05):肌酸激酶(CK)47.44%、肌酸激酶同工酶(CK-MB)51.28%、门冬氨酸氨基转移酶(AST)42.31%、乳酸脱氢酶(LDH)42.31%、α-羟丁酸脱氢酶(α-HBDH)44.87%。cTnT和cTnI阳性组ECG正常率5.26%,9.62%)明显低于阴性组(71.43%.57.69%)(P<0.05)。结论在病毒性心肌炎的诊断中cTnT和cTnI可取代传统的心肌酶谱测定作为判断急性心肌炎的指标;同时cTnT和cTnI在病毒性心肌炎病情进展的观察中也具有重要意义。Objective To investigate the utility of cardiac troponin T（cTnT） and cardiac troponin I （cTnI） in diagnosing viral myocarditis （VMC）. Methods To constantly monitoring 78 VMC patients for 1,2, 3 weeks and 2 months after their admission. And to compare their cTnT and cTnI results with their various biochemical items, such as creatine kinase（CK）, creatine kinase MB （CK-MB） , aspartate aminotransferase fAST）, lactate dehydrogenase（LDH）, α-hydroxybutyrate dehydrogenase （α-HBDH）. Results In acute VMI patients, all the positive rate of cTnT（73.8%） and cTnI（66. 7%） were much higher than those other biochemical items： CK 47.44%,CK-MB 51.28%,AST 42.31%, LDH 42. 31%,α-HBDH 44.87%. The normal ECG in cTnT and cTnI positive group were much lower than that in the negative group （P〈0.05）. Conclusion cTnT and cTnI can be used as useful alternatives to the mostly used biochemical items for diagnosing the acute VMI. Moreover, these two items can also play important role in observing the later development since the outset of VMC.

关 键 词：肌钙蛋白 心肌炎 实验室诊断 

分 类 号：R542.21[医药卫生—心血管疾病] R540.4[医药卫生—内科学]