尿中2-硫代噻唑烷-4-羧酸排泄规律初探  

Preliminary Study on Pattern of Urinary Excretion of 2 thiothiazolidine 4 carboxylic Acid by Workers Exposed to Carbon Disulfide

作　　者：简乐[1] 王红妹[1] 曹文俊[1] 胡迪生[1] 

机构地区：[1]浙江医科大学公共卫生学院

出　　处：《中国公共卫生学报》1997年第4期240-241,共2页

摘　　要：对１５名二硫化碳（ＣＳ２）作业工人与１４名非接触者进行了尿２硫代噻唑烷４羧酸（ＴＴＣＡ）排泄规律研究。结果表明，随ＣＳ２接触时间与接触量的增加，ＴＴＣＡ水平逐渐增高（班前、班中、班末ＴＴＣＡ几何均数分别为１．２５７４、１．６１２０、２．１８０５／ｇｃｒ），呈剂量效应关系。停止接触后ＴＴＣＡ排泄较快，１６ｈ后基本降至前一天班前水平。班末尿ＴＴＣＡ能灵敏地反映个体近期ＣＳ２接触量。４２个非接触者尿样中有３２个检出微量ＴＴＣＡ（７６．２％），其ＴＴＣＡ排泄无明显特征。The pattern in the urinary excretion of 2 thiothiazolidine 4 carboxylic acid (TTCA) was studied in 15 workers exposed to carbon disulfide(CS 2) and 14 control persons.it was found that the urinary TTCA levels(the geometric mean were 1.2574,1.6120 and 2.1805 mglgcr respectively in before shift,middle shift and end shift urine) were related to the time of exposure and the doses of CS 2 TTCA excreted rapidly after exposure and almost droped to original levels next morning.Thus,the end shift urinary TTCA levels can sensitively reflect the levels of recent CS 2 exposure.Trace of TTCA was detected in 32142 urine samples of non exposed persons.The quantity of TTCA urine was diversified.In addition,elevated urinary TTCA levels were found after drinking white wine in control group.The significance of the finding needs further study.

关 键 词：二硫化碳 生物监测 TTCA 作业工人 

分 类 号：R135.1[医药卫生—劳动卫生]