硫酸亚铁对豚鼠心脏慢反应动作电位的影响  

Effects of Ferrous Sulfate on Slow Action Potentials in Guinea Pig Myocardium

作　　者：马欣[1] 赵松珍[1] 

机构地区：[1]西安医科大学药理学教研室 [2]西安医科大学第一临床学院神经内科

出　　处：《中国公共卫生学报》1997年第4期249-250,共2页

基　　金：国家自然科学基金

摘　　要：用细胞内固定微电极技术观察了硫酸亚铁对豚鼠心肌慢反应动作电位的作用。硫酸亚铁０．１～０．２ｍｍｏｌ．Ｌ－１能显著减慢ＡＰ的Ｖｍａｘ和ＡＰＡ，对高Ｋ＋诱发的慢ＡＰ尚有抑制作用。并可对抗哇巴因诱发的豚鼠心室肌振荡后电位。结果表明。The effects of FeSO 4 on slow action potentials of guinea pigs were studied with intracellular microelectrodes.FeSO 4 0.1～0.2mmol.L -1 decreased the maximal upstroke velocity (V max ) and the amplitude of slow action potentials.An inhibitory influence of FeSO 4 on the action potential amplitude was observed in papillary muscles superfused with Tyrode′s solution containing high K +.FeSO 4 inhibited the guinea pig papillary muscle oscillatory afterpotential induced by ouabain.The results suggest that FeSO 4 possesses calcium antagonistic effect.

关 键 词：硫酸亚铁 慢反应动作电位 乳头状肌 

分 类 号：R977.9[医药卫生—药品] R965.2[医药卫生—药学]