IL-1对大鼠脑组织β淀粉样前体蛋白基因表达的影响  

THE EFFECT OF IL-1 ON β AMYLOID PRECURSOR PROTEIN GENE EXPRESSION IN RAT BRAIN

作　　者：宋宇蓓[1] 王少文[1] 张迺蘅[1] 马康涛[1] 

机构地区：[1]北京医科大学生物化学与分子生物学系,100083

出　　处：《北京医科大学学报》1997年第3期202-203,210,共3页Journal of Peking University(Health Sciences)

基　　金：国家教委博士点基金

摘　　要：目的：研究在整体动物水平白细胞介素1（interleukin1，IL－1）对β淀粉样前体蛋白（βamyloidprecursorprotein，APP）基因表达的影响。方法：大鼠侧脑室注射；Northern杂交。结果：首次证实IL－1β在整体动物水平可以诱导大鼠脑组织APPmRNA表达的增加，而且这种诱导作用具有时间依赖性。结论：IL－1β在体内、外均可诱导神经组织内APP基因的表达增加，进而在阿尔茨海默病（Alzheimerdisease，AD）中与促进β淀粉样蛋白（βamyloidprotein，βAP）的沉积可能密切相关。Objective: To find the effect of IL-1 on APP gene expression in vivo. Methods: Rat intracere-broventricular(i. c. v. ) injection; northern hybridization. Results: For the first time we have reported that in vivo IL-1β can increase APP mRNA expression and that this enhancement is time dependent.Concluslon:To some degree IL-1β can enhance APP gene expression both in vivo and in vitro. The results suggest a role of IL-1β in the neuronal mechanisms related to β9-amloid protein deposition in AD.

关 键 词：白细胞介素1 药理学 基因表达 Β淀粉样 

分 类 号：R979.5[医药卫生—药品]