阿德福韦酯联合肝络欣丸治疗HBeAg阳性的慢性乙型肝炎24周疗效观察  

The efficacy of HBeAg-positive chronic hepatitis B with Adefovir dipivoxil and Ganluoxin pills in 24 weeks

作　　者：王原[1] 余亮科[1] 曹克勇[2] 张瑞凤[1] 张羽忠[1] 

机构地区：[1]华北煤炭医学院附属医院感染性疾病科,河北唐山063000 [2]华北煤炭医学院临床医学系,河北唐山063000

出　　处：《临床肝胆病杂志》2007年第6期428-429,共2页Journal of Clinical Hepatology

摘　　要：目的为评价阿德福韦酯联合肝纤欣丸治疗HBeAg阳性慢性乙型肝炎患者24周的疗效。方法对52例HBeAg阳性慢性乙型肝炎患者分别给予阿德福韦酯联合肝络欣丸治疗和阿德福韦酯单药治疗,观察治疗24周期间,在第16周、24周末肝功能中的丙氨酸氨基转移酶(ALT)、HBV DNA变化。结果阿德福韦酯和肝络欣丸联合应用在降低HBV DNA和ALT水平,提高HBV DNA转阴率、ALT复常率方面疗效均优于单用阿德福韦酯。结论阿德福韦酯和肝络欣联用疗效优于单用阿德福韦酯。Objective To evaluate the efficacy of HBeAg - positive chronic hepatitis B with Adefovir dipivoxil and Ganluoxin pills in 24 weeks. Methods 52 patients with HBeAg - positive chronic hepatitis B were treated with Adefovir dipivoxil and Ganluoxin pills or Adefovir dipivoxil alone. In this 24 weeks, we mostly observed the change of the level of ALT and HBV DNA at the end of 16th and 24th week. Results The efficacy of the patients with HBeAg - positive chronic hepatitis B who were treated with Adefovir dipivoxil and Ganluoxin is higher than those were treated with Adefovir dipivoxil alone in the decrease of ALT and HBV DNA, and in the increase of the negative rate of HBV DNA and the recovery rate of ALT. Conclusion The efficacy of Adefovir dipivoxil and Ganluoxin pills is higher than that of adefovir dipivoxil alone.

关 键 词：阿德福韦酯 肝络欣丸 E抗原 乙型肝炎 疗效 

分 类 号：R512.62[医药卫生—内科学]