枸杞多糖的化学研究  

STUDIES ON THE CHEMISTRY OF GOUQI POLYSACCHARIDES

作　　者：赵春久[1] 李荣芷[1] 何云庆[1] 崔国辉 

机构地区：[1]北京医科大学药学院中药研究室,吉林省药物研究所100083 [2]北京医科大学药学院物理化学教研室,100083

出　　处：《北京医科大学学报》1997年第3期231-232,240,共3页Journal of Peking University(Health Sciences)

摘　　要：目的：研究宁夏枸杞（LyciumbarbarumL）果实（枸杞子）水溶性活性多糖的化学。方法：采用DEAE柱层析分离多糖均一体，以抗脂质过氧化为指标，追踪枸杞多糖的活性。结果：获得并鉴定四个抗脂质过氧化活性多糖均一体。除LBPC。分子量1.0×104，为α－（1→4）（1→6）连接的葡聚糖肽外，LB－PA3、LBPB1、LBPC2分别为分子量6.6×104、1．8×104、1.2×104，β-（1→4）（1→6）连接的杂多糖肽。结论：鉴定了四个枸杞多糖均一体的化学结构，证明它们均为抗脂质过氧化的活性成分。objective: To study the chemistry and pharmacological activity of Gouqizi(Lycium barbarum L)water soluble polysaccharide. Methods:Screened with resisting liqid peroxidation, the effective ingredients were isolated with ion exchange chromatography on DEAE-cellulose. ResuIts: Four homogenous polysaccharides were obtained and identified. These homogenous polysaccharides were found to be effeetive ingredients with resisting lipid peroxidation.Homogenous polysaccharide LBPC4 was proved to be a peptidoglycan with MW of 1.0×104,composed of glucans,while LBPA3.LBPB1.LBPC2 were proved to be peptidoglycans with MWs of 6.6 ×104, 1. 8 ×104, 1. 2 ×104, respectively, composed of heteroglycan.Conclusion :The chemical structures of four homogenous polysaccharides were identified and they were proved to be effective ingredients with resisting lipid peroxidation.

关 键 词：枸杞 多糖类 分离 提纯 

分 类 号：R284.1[医药卫生—中药学]