失血性休克早期白细胞介素1活性变化  

Changes of IL - 1 activity in the early phase of hemorrhagic shock

作　　者：石汉平[1] 黄祥成 齐德林 徐仁宝[2] 高瀚[3] 徐洁[4] 杨瑞和[4] 

机构地区：[1]广州南方医院普外科,广州510515 [2]第二军医大学病理生理教研室 [3]上海长征医院普外科 [4]上海长海医院急诊科

出　　处：《中国病理生理杂志》1997年第3期317-320,共4页Chinese Journal of Pathophysiology

摘　　要：观察失血性休克早期大鼠、病人IL—1活性变化,大鼠30％失血后,腹腔巨噬细胞分泌IL—1的能力2h内逐渐升高,随后下降,至4h有明显抑制。血浆IL—1活性于2.5h达峰值,随后逐渐下降,无应激大鼠及假处理大鼠IL—1活性均无显著变化。失血性休克患者急诊入院时血浆IL—1活性也显著升高,与健康志愿者相比差异显著,其机制及意义有待探讨。The in vivo and in vitro changes of IL-1 activity in the early phase of hemorrhagic shock of rats and patient were observed. Experimental hemorrhagic shock model was produced by exsanguinate 30% of rats total blood volume. Hemorrhagic shock patient was affirmed according to bloodloss history and brachial artery pressure. IL - 1 activity was detected by improved lymphocyte-activating factor (LAF) method. It was found that there was an initial increase and followed by a decrease in plasma IL-1 activity as well as IL-1 secreting capacity of peritoneal macrophage in the intial 4 hours of shock. However there was no obvious change of IL -1 activity in nonstress or sham rat. Shock patients just like shock rats also exhibited an enhanced plasma IL-1 activity at time of admission, but the volunteer did not. The mechanism and meaning of IL-1 alteration in hemorrhagic shock is worth further study.

关 键 词：出血性休克 白细胞介素1 

分 类 号：R605.972[医药卫生—急诊医学]