抗菌水凝胶的合成及性能研究  

Study on synthesis and properties of hydrogels with anti-bacterial activity

作　　者：李小红[1] 董勤正[1] 张静[1] 何培新[1] 

机构地区：[1]湖北大学 化学化工学院,湖北武汉430062

出　　处：《湖北大学学报（自然科学版）》2007年第4期392-395,412,共5页Journal of Hubei University：Natural Science

基　　金：有机功能分子合成与应用教育部重点实验室资助项目(2005-KL-011)

摘　　要：用溴乙烷和甲基丙烯酸二甲胺基乙酯合成N,N-二甲基,N-乙基甲基丙烯酰氧乙基溴化铵,并以此含取代乙烯基结构的季铵盐(DMAEA-EB)、丙烯酸(AA)和丙烯酰胺(AM)为原料,十八烷基磷酸单酯为分散剂.通过反相悬浮聚合法合成含有阴阳两种离子的高吸水性树脂(SAP),讨论丙烯酸、丙烯酰胺、季铵盐、引发剂、交联剂用量对产物吸水性能的影响,并以大肠杆菌(E.coli)、猪葡萄球菌(S.hyicus)为对象,初步讨论树脂的抗菌性能.结果表明在AA/AM=1/1,n(DMAEA-EB)=2%(占单体的摩尔百分数),引发剂用量为0.754%,交联剂用量为0.01%。丙烯酸中和度为75%,反应温度为70℃的条件下,制得的SAP吸去离子水可达1035 g/g.吸0.9%的NaCl溶液为114 g/g.当季铵盐含量为2%时,抗菌效果较好,抗菌率达90%以上.A series of hydrogels with antibacterial activity were synthesized from N, N-dimethyl,N- ethylmethacryloxylethylammoniumbromide（DMAEA-EB）, aerylic acid （AA） and acrylamide （AM） by inverse suspension polymerization, using mono-oetadeeyl phosphate as dispersant. The effect of monomer concentration, initiator concentration, crosslinker content on the swelling ratio were investigated. The optimum reaction conditions were determined： AA/AM= 1/1, n （DMAEA-EB）= 2%,n （NMBA） 0. 01%, n（KPS） =0. 754%, reaction temperature 70℃ and reaction time 2. 5 h. Under these conditions the copolymer obtained can absorb 1 035 g（H2O） and 114 g NaCl solution [w （NaCl）= 0.9%] per gram. Aiming at E. coli and S. hyicus, The influence of the content of DMAEA- EB on antibacterial avtivity was studied. When the contentration of DMAEA-EB is 20%, the antibacterial efficience is the best.

关 键 词：高吸水性树脂 不饱和季铵盐 丙烯酸 反相悬浮聚合 抗菌性 

分 类 号：TQ316[化学工程—高聚物工业] O647.2[理学—物理化学]