格拉司琼用于预防术后自控镇痛中呕吐的观察  

Observation of Granisetron Hydrochloride in Prevention of Postoperative Vomiting Associated with Patient-Controlled Analgesia

作　　者：何崎[1] 张欢[1] 田丹[1] 谢阿奇[1] 

机构地区：[1]成都市中西医结合医院,四川成都610017

出　　处：《现代临床医学》2007年第6期454-455,共2页Journal of Modern Clinical Medicine

摘　　要：目的:比较氟哌利多和格拉司琼两药对术后自控镇痛中呕吐的预防作用。方法:选择腹部手术后病人90例进行自控镇痛,分为A、B、C 3组,各30例,术前术中不用止吐药,3组均加入镇痛药芬太尼1 mg,其中A组再加入格拉司琼3 mg,B组再加入氟哌利多5 mg,C组作为对照。各组均加生理盐水至100 mL,术毕均各给5 mL稀释药液为负荷量,然后用机械泵静脉泵注2 mL.h-1。结果:呕吐发生率A组<B组(P<0.05),B组<C组(P<0.05),B组嗜睡发生率高于A、C组(P<0.05)。结论:格拉司琼较氟哌利多止吐作用明显且副作用少。Objective：To compared the efficacy and safety of Granisetron hydrochloride and Droperidol in the prevention of postoperative vomiting associated patients with abdominal operations received patient with patientcontrolled analgesia. Methods： Ninety - controlled analgesia and were randomly divided into groups A, B, and C with 30 patients in each group. No antiemetic drugs were used for every group before and during operation. All the test groups received analgesic drug, fentanyl 1 mg, wherein group A received Granisetron hydrochloride 3 rag, group B received Droperidol 5 mg and group C was the normal control group. Local anesthetics were diluted to 100 mL with 0.9% physiological saline in each group. Total 5 mL diluted solution was used as loading dose for each group respectively after operation and then injected the solution of 2 mL· h^-1 via vein with mechanical pump. Results： The incidence of vomiting in group A was significantly lower than in group B （P 〈0.05）and group B lower than in group C（P 〈0.05）. And the incidence of somnolence of Group B was more frequent than that of Group A and Group C （P 〈 0. 05 ） . Conclusion： Granisetron hydrochloride has better antiemetic effect with less side effect comparing with Droperidol in the prevention of postoperative vomiting associated with patient - controlled analgesia.

关 键 词：格拉司琼 氟哌利多 自控镇痛 呕吐 

分 类 号：R614.2[医药卫生—麻醉学]