外科创伤后炎性反应和免疫抑制  

Surgical Trauma-induced Inflammatory Reaction and Immunosuppression

作　　者：何亮[1] 钱燕宁[2] 

机构地区：[1]南京医科大学第二附属医院麻醉科,南京210011 [2]南京医科大学第一附属医院麻醉科,南京210029

出　　处：《医学综述》2007年第15期1121-1123,共3页Medical Recapitulate

基　　金：江苏省医学重点人才项目(RC2002058)

摘　　要：研究证实外科创伤后机体的免疫系统功能受到抑制,反映在创伤早期的过度炎性反应和随后的细胞免疫抑制。术后免疫系统功能紊乱是术后感染,败血症和多器官功能衰竭等并发症的发病原因之一。临床医师通过免疫调节可改善创伤后免疫抑制。本文概述外科创伤介导的免疫抑制的机制和免疫调节治疗研究进展。Studies have testified that immune system of the body was suppressed afer having surgical trauma, which can be shown by the excessive inflammatory reaction and the following cell immunosuppression during early period. Functional disorder of immune system after operation is the main cause of complications including postoperation infection, septicemia, multiple organ failure and so on. Clinical doctors can improve post trauma immunosuppression by immunoloregulation. This article reviews study progresses of mechanism of immunosupression induced by surgical trauma and its immunotherapy.

关 键 词：创伤和损伤 炎性反应 免疫抑制 

分 类 号：R641[医药卫生—外科学]