腺苷负荷心肌灌注显像诊断冠心病的临床应用  

Clinical Application of Adenosine Stress Myocardial Perfusion Imaging for Detection Coronary Artery Disease

作　　者：赵峰[1] 曾斌[2] 

机构地区：[1]宁夏医学院附属医院核医学科,银川750004 [2]银川市第一人民医院内九科,银川750001

出　　处：《宁夏医学院学报》2007年第6期596-598,共3页Journal of Ningxia Medical College

摘　　要：目的评价腺苷负荷心肌灌注显像对冠心病诊断的临床应用价值。方法住院疑诊冠心病患者53例,静息心肌灌注显像24h后行腺苷负荷心肌灌注显像,记录患者注射腺苷过程中的心率、血压及临床症状。所有患者2周内行冠状动脉造影,以冠状动脉造影为"金标准",分析腺苷负荷心肌灌注显像对冠心病诊断的敏感性、特异性等指标。结果腺苷负荷心肌灌注显像诊断冠心病的敏感性为88.9%,特异性70.6%,阳性预澍值86.5%,阴性预测值75.0%,准确性83.0%。诊断单支、二支和三支冠状动脉病变的敏感性分别为78.6%、90%和100%。整个过程中未发生严重不良反应。结论腺苷负荷心肌灌注显像对冠心病的诊断有较高的敏感性和特异性,可作为运动负荷心肌灌注显像的重要补充,值得在临床推广和应用。Objective To assess the sensitivity, specificity and its clinical application of adenosine stress myocardial imaging on coronary artery disease（CAD）. Methods 53 cases suspiciously diagnosed CAD were performed with Adenosine stress myocardial perfusion imaging after resting myocardial perfusion imaging in 24 hours, and the heart rate, blood pressure and clinical symptom during injecting adenosine were recorded. All patients were performed with coronary angiography in the 2 weeks. Results The sensitivity, specificity and accuracy of adenosine stress myocardial perfusion imaging for detection of CAD were 88.9%, 70.6% ,83.0% respectively. The positive predictive value and negative predictive value was 86.5% and 75.0%. The sensitivity of single,two and three coronary artery disease was 78.6% ,90% and 100% respectively. There is no severe accident during injecting adenosine. Conclusion Adenosine stress myocardial perfusion imaging has a higher sensitivity and specificity in diagnosis of CAD. It can be an important additional method of exercise stress myocardial perfusion imaging and deserve to utilize and to spread in the clinic practice.

关 键 词：腺苷 放射性核素 冠状动脉疾病 心肌灌注显像 

分 类 号：R541.4[医药卫生—心血管疾病]