高浓度模拟体液仿生合成快速制备羟基磷灰石涂层  

Preparation of Hydroxyapatite Coating in Concentrated Simulated Body Fluid by Accelerated Biomimetic Synthesis

作　　者：李亚东[1] 刘敬肖[1] 史非[1] 唐乃岭[1] 于玲[1] 

机构地区：[1]大连轻工业学院化工与材料学院,大连116034

出　　处：《生物医学工程学杂志》2007年第6期1314-1318,共5页Journal of Biomedical Engineering

基　　金：辽宁省教育厅A类攻关项目资助(202073425);辽宁省博士启动基金项目资助20021054)

摘　　要：采用三种不同的预处理工艺对NiTi合金基体进行活化处理,利用柠檬酸作为缓冲剂配制高浓度模拟体液(Simulated body fluid,SBF)5×SBF1和5×SBF2,通过仿生合成在预处理后的NiTi合金基体上快速形成了钙磷涂层。对钙磷涂层的显微结构、组成和形貌进行了研究,结果表明:涂层呈多孔网状,由直径小于3μm的球形颗粒堆积而成,X射线衍射(XRD)测试显示其主要成分为羟基磷灰石;而缺少晶体生长抑制剂Mg2+和HCO3-的5×SBF高浓度模拟体液则明显地加快了羟基磷灰石涂层的形成。In the present work, NiTi alloy substrates were activated by three different pretreatment processes. 5 × SBF1 and 5× SBF2 concentrated simulated body fluids were prepared with citric acid buffer reagent, and then calcium phosphate coatings were formed quickly on NiTi alloy surface by accelerated biomimetic synthesis after pretreatment. The microstructure, composition and surface morphology of calcium phosphate coatings were studied. The results indicate that calcium phosphate coatings possess porous and net structure, which are composed of precipitated spherical particles with diameter less than 3 μm. The analysis of XRD shows that the main component of calcium phosphate coatings is hydroxyapatite,whereas the concentrated 5 ×SBF simulated body fluid, which is in the absence of Mg^2＋ and HCO3- crystal growth inhibitors, apparently accelerates the growth rate of hydroxyapatite coatings.

关 键 词：预处理 柠檬酸 高浓度模拟体液 仿生合成 羟基磷灰石涂层 

分 类 号：R318.08[医药卫生—生物医学工程]