中西医结合治疗对去卵巢大鼠骨生物力学的影响  

Effects of Chinese medicine combined with western medicine on bone biomechanics in ovariectomized rats

作　　者：常小霞[1] 吴洁[2] 任慕兰[1] 马戎[2] 许萍[2] 

机构地区：[1]南京市东南大学附属中大医院妇产科,南京210009 [2]南京大学医学院附属鼓楼医院

出　　处：《中国骨质疏松杂志》2007年第12期833-836,共4页Chinese Journal of Osteoporosis

基　　金：南京市卫生局科研课题(YKK05101;YKK05124)

摘　　要：目的探讨中西医结合治疗对去卵巢大鼠骨生物力学的影响。方法70只3月龄未交配的雌性SD大鼠腹腔手术切除双侧卵巢,按体重随机分为去卵巢组、17α-炔雌醇组、益坤口服液中剂量组、益坤口服液大剂量组2、益坤小剂量+戊酸雌二醇组、益坤小剂量+17α-炔雌醇组,并设假手术组对照。喂养12周后,分离大鼠股骨,三点弯曲实验法测定最大载荷、最大桡度、弹性载荷、弹性桡度及弹性能量吸收,分析天平称骨量。结果大鼠去卵巢后股骨结构力学特性指标均显著下降,各用药组与OVX组相比均有显著上升,其中中西医结合治疗组更加显著(P<0.01)。结论中西医结合治疗可改善去卵巢大鼠骨的生物力学性能,降低其发生骨折的危险性。Objective To explore the benefit effects of Chinese medicine combined with Western medicine on bone biomechanics in ovariectomized（OVX） rats. Methods 70 virgin female Sprague-Dawley rats, 3 months of age, were randomized by the stratified weight method into 7 groups： （1） Sham group; （2） OVX group; （3） OVX ＋ 17α-ethinylestradiol group; （4） OVX ＋ Yikun oral liquid middle dose group; （5） OVX ＋ Yikun oral liquid large dose group; （6） OVX ＋ Yikun oral liquid low dose ＋ estradioi valerate group; （7） OVX ＋ Yikun oral liquid low does group ＋ 17a-ethinylestradiol group. After having been fed for 12 weeks, the rats were killed and femur were separated, maximum load, maximum deformation, elastic load, elastic deformation and energy absorption were measured from the three point bending test. Bone wet weights were measured by the analytic balance. Results The femur biomechanics markers of OVX group decreased obviously, while that of all medicated group increased obviously especially the group of Chinese medicine with western medicine （ P 〈 0.01 ）. Conclusion Chinese medicine combined with western medicine had benefit effects on bone biomechanics property and decreased the risk of the bone fracture.

关 键 词：中西医结合 去卵巢大鼠 骨生物力学 骨质疏松 

分 类 号：R692.05[医药卫生—泌尿科学]