血浆脑钠肽预测OPCAB术后并发症的临床研究  

Utility of B-Natriuretic Peptide in Predicting Post Operative Complications in Patients Undergoing OPCAB

作　　者：宋静华[1] 郭志刚[1] 李军山[1] 魏民新[1] 孙静[1] 杨东艳[1] 王联群[1] 姜楠[1] 

机构地区：[1]天津市胸科医院心外科,300051

出　　处：《天津医药》2007年第12期912-914,共3页Tianjin Medical Journal

摘　　要：目的:探讨血浆脑钠肽(BNP)水平对于评价非体外循环下冠状动脉旁路移植术(OPCAB)术后并发症的临床价值。方法:以OPCAB患者130例为研究对象。分别于手术前、术后5h、术后24h、术后72h及术后1周测定血浆BNP水平,分析术后BNP的变化趋势。将血浆BNP水平与术后早期心律失常等临床事件进行分析。结果:(1)OPCAB术后5h血浆BNP水平开始上升,72h达峰并开始下降,到1周时仍明显高于术前水平(P<0.01)。(2)术后心律失常组术前、术后24h、72h及1周的血浆BNP水平高于非心律失常组(P<0.01或P<0.05)。结论:(1)OPCAB术后血浆BNP水平呈动态变化趋势。(2)术前及术后升高的血浆BNP水平可能与术后心律失常有关。Objective： To investigate the ehanges of serum brain natriuretie peptide （BNP） in patients undergoing off- pump coronary artery bypass grafting （OPCAB） and to assess whether BNP eould be used as predietors of postoperative eomplieatians in patients after OPCAB. Methods： There were 130 patients admitted to the study. The serum levels of BNP were measured before surgery and at 5 h ,24 h ,72 h and 7 d after the operation. Results： The serum levels of BNP elevated markedly at 5 h after operation and reaehed peak value at 72 h after operation then deereased but was still higher than before operation （P 〈 0.01）. The serum levels of BNP were signifieantly higher before and at 24 h,72 h and 7 d after operation in patients with arrhythmias eompared to those in patients without arrhythmias （P 〈 0.01 or P 〈 0.05）. Conclusion： The elevated serum levels of BNP before and after OPCAB were asseeiated with postoperative eomplieations, arrhythmias.

关 键 词：利钠肽 脑 冠状动脉旁路移植术 非体外循环 手术后并发症 心律失常 

分 类 号：R654.2[医药卫生—外科学]