肾石消片提取工艺优选研究  

Optimization of the Extraction Technology of Shenshixiao Tablet

作　　者：赵琳[1] 童晓青 佟占柱 陈翠英[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]山东烟台鲁银药业有限公司,264002 [3]辽宁省营口市天鑫药业有限公司,115000

出　　处：《时珍国医国药》2007年第12期3072-3073,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的针对肾石消片的提取工艺进行研究。方法通过正交试验以处方中金钱草中所含总黄酮的提取量和出膏率为定量指标,确定合理的醇提取工艺。结果醇提取最佳工艺条件是:乙醇浓度为60%,加醇量为10,8,8倍,提取3次,第1次提取1.5h,第2次、第3次分别提取1 h,出膏率及有效成分提取率均较高,且重现性较好。结论优选得到的工艺稳定可行,适合工业大生产要求。Objective To study the optimum extracting process of Shenshixiao tablet, Methods The proper extracting condition was optimized by orthogonal tests with the amount of extracted total flavonoids and the ratio of poultice as index in Herba Lysimachiae. Results The proper extracting condition with alcohol of which the concentration was 60 percent. The herbs were extracted with 10, 8 and 8 times alcohol for 3 times while 1.5 hours for the first time and 1 hour for the second and the third time respectively. As a result, the amount of extracted total flavonoids and the ratio of poultice were high and reoccurred well. Conclusion Optimized process condition is scientific, stable and practicable in manufacture.

关 键 词：提取工艺 正交设计 紫外分光光度法 总黄酮 

分 类 号：R284.2[医药卫生—中药学]